Dr Andre Neves

University of Cambridge

University departments
Cancer Research UK Cambridge Institute
Department of Oncology
Department of Biochemistry
University institutes
CRUK Cambridge Institute
NHS or other affiliations
Fellow of Homerton College

Position: Senior Research Associate
Personal home page: http://www.researchgate.net/profile/Andre_Neves/

PubMed journal articles - click here

Research description

As a chemical engineer, I enjoy translating basic science into novel biomedical technologies. I am interested in the use of molecular imaging techniques for early cancer diagnosis and for better assessing response to cancer therapy. Currently, I'm planning a first-in-human clinical trial of a novel cell death imaging agent, C2Am. This new imaging scan will enable clinicians to assess more accurately and rapidly the patient's response to cancer therapies, potentially leading to better outcomes and significant cost savings.

Research Programme
Advanced Cancer Imaging
Secondary Programme
Early Detection
Methods and technologies
Biosensor
Cell culture
Clinical trials
Fluorescence microscopy
HPLC/FPLC
Imaging
In vivo modelling
Model organisms
Protein biochemistry
Protein purification
Proteomics
Recombinant protein expression
Tumour type interests
Breast
Cervix
Colorectal
Oesophagus
Pancreas
Keywords
molecular imaging
early detection
atrmdn2
Recent publications:
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Key publications

[1] Rapid Imaging of Tumor Cell Death in vivo using the C2A domain of Synaptotagmin-I.
Neves AA, Xie B, Fawcett S, Alam IS, Witney TH, de Backer MM, Summers J, Hughes W, McGuire S, Soloviev D, Miller J, Howat WJ, Hu DE, Rodrigues TB, Lewis DY, Brindle KM.
J Nucl Med. 2017 58(6), 881-7.

[2] Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.
Neves AA, Wainman YA, Wright A, Kettunen MI, Rodrigues TB, McGuire S, Hu DE, Bulat F, Geninatti Crich S, Stöckmann H, Leeper FJ, Brindle KM.
Angew Chem Int Ed Engl. 2016 Jan 22;55(4):1286-90.

[3] Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus.
Bird-Lieberman EL, Neves AA, Lao-Sirieix P, O'Donovan M, Novelli M, Lovat LB, Eng WS, Mahal LK, Brindle KM & Fitzgerald RC
Nat Med. 2012 18(2):315-21.

Illustration of the C2Am imaging agent (yellow) binding to a dying cancer cell (blue) [1]