Professor Bertie Gottgens

University of Cambridge

University departments
Department of Haematology
University institutes
Wellcome Trust MRC Cambridge Stem Cell Institute

Position: Professor
Personal home page: http://www.stemcells.cam.ac.uk/researchers/principal-investigators/bertie-gottgens

PubMed journal articles - click here

Professor Bertie Gottgens is pleased to consider applications from prospective PhD students.

Research description

The Göttgens group uses a combination of experimental and computational approaches to study how transcription factor networks control the function of blood stem cells and how mutations that perturb such networks cause leukaemia. This integrated approach has resulted in the discovery of new combinatorial interactions between key blood stem cell regulators, as well as experimentally validated computational models for blood stem cells. Current research focuses on (i) single cell genomics of early blood development, (ii) computer models to chart the transcriptional landscape of blood stem and progenitor cell differentiation, (iii) transcriptional consequences of leukaemogenic mutations in leukaemia stem/progenitor cells, and (iv) molecular characterisation of human blood stem/progenitor cell populations used in cell and gene therapy protocols.

Research Programme
Haematological Malignancies
Secondary Programme
Onco-Innovation
Tumour type interests
Leukemia
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Recent publications:
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Key publications

Wilson NK, Kent DK, Buettner F, Shehata M, Macaulay IC, Calero-Nieto FJ, Sánchez Castillo M, Oedekoven CA, Diamanti E, Schulte R, Ponting CP, Voet T, Caldas C, Stingl J, Green AR, Theis FJ, Göttgens B. (2015). Combined single cell functional and gene expression analysis resolves heterogeneity within stem cell populations Cell Stem Cell 16(6): 712-724.

Moignard V, Woodhouse S, Haghverdi L, Lilly AJ, Tanaka Y, Wilkinson AC, Buettner F, Macaulay IC, Jawaid W, Diamanti E, Nishikawa S, Piterman N, Kouskoff V, Theis FJ, Fisher J, Göttgens B. (2015). Decoding the Regulatory Network for Blood Development from Single-Cell Gene Expression Measurements. Nat Biotech 33(3): 269-276.

Moignard V, Macaulay IC, Swiers G, Buettner F, Schütte J, Calero-Nieto FJ, Kinston S, Joshi A, Hannah R, Theis FJ, Jacobsen SE, de Bruijn MFT, Göttgens B. (2013) Characterisation of transcriptional networks in blood stem and progenitor cells using high-throughput single cell gene expression analysis. Nature Cell Biology 15: 363-372.

Griffiths DS, Li J, Dawson MA, Trotter M, Cheng Y-H, Smith AM, Mansfield W, Liu P, Kouzarides T, Nichols J, Bannister AJ, Green AR, Göttgens B. (2011). LIF independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. Nature Cell Biology 13: 13-21.

Wilson NK, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska P, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B. (2010) Combinatorial Transcriptional Control in Blood Stem/Progenitor Cells: Genome-wide Analysis of 10 major Transcriptional Regulators. Cell Stem Cell 7(4):532-544.