Professor Brian Huntly
Position: Senior Clinical Fellow
Personal home page: https://www.cimr.cam.ac.uk/research/affiliated/huntly
PubMed journal articles - click here
Professor Brian Huntly is pleased to consider applications from prospective PhD students.
Our aim is to further characterise the molecular and cellular biology of cancer stem cells and to compare and contrast these to normal stem cells. To do so, we utilise malignant and normal haematopoiesis as our model system and use complementary genetic, genomic and functional analyses of both mouse models and primary patient material. We are concentrating on transcriptional alterations in the generation and maintenance of leukaemia stem cells and are examining self-renewal programmes downstream of leukaemia-associated oncogenes and a known self-renewal pathway, the CDX-HOX axis in AML. Furthermore, we are assessing the role of specific genes in the generation and maintenance of leukaemia stem cells, using murine conditional knock-out strains. Our long-term aim is to identify and validate targets which will allow specific treatment of leukaemia and cancer stem cells with acceptable side-effects on normal adult stem cells.
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Huntly BJP, Shigematzu H, Deguchi K, Lee BH, Mizuno S, Duclos N, Rowan R, Amaral S, Curley D, Williams IR, Akashi K and Gilliland, DG. MOZ-TIF2, but not BCR-ABL, confers properties of leukaemic stem cells to committed murine haematopoietic progenitors. Cancer Cell. 2004; 6: 586-595 Huntly BJP and Gilliland DG. Leukemia Stem Cells and the Evolution of Cancer Stem Cells. Nature Reviews Cancer. 2005; 5: 311-321 Bansal D, Scholl C, Frohling S, McDowell E, Lee BH, Dohner K, Ernst P, Davidson A, Daley GQ, Zon LI, Gilliland DG and Huntly BJP. Cdx4 upregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A. 103:16924-9. Epub 2006 Oct 26.