Dr Bristi Basu

University of Cambridge
Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Honorary Consultant Medical Oncologist

Position: Academic Consultant in Experimental Cancer Therapeutics
Personal home page:
Email:   bristi.basu@cruk.cam.ac.uk

PubMed journal articles - click here

Research description

My research focus is in drug development and I translate preclinical findings on lead candidate agents into early phase clinical trials of novel therapeutic drugs as chief investigator, principal investigator and co-investigator in academic-led and industry-sponsored Phase I, II and III clinical trials, including first-in-human studies. My tumour site-specific focus is in hepato-pancreatico-biliary cancers, for which I am designing novel clinical trials based on preclinical research that has been performed at the Cambridge Pancreatic Cancer Centre. I am involved in projects of non-invasive imaging techniques that evaluate pharmacodynamic effects or show potential as early predictors for efficacy of anticancer drugs.

Research Programme
Pancreatic Cancer
Tumour type interests
Gallbladder
Liver
Ovary
Pancreas
Keywords
Phase I trials
imaging studies
pancreatic cancer
HCC
ovarian cancer
bb313
Recent publications:
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Key publications

“First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor, AZD2014” B Basu*, E Dean*, M Puglisi, A Greystoke, M Ong, W Burke, M Cavallin, G Bigley, C Womack, E A Harrington, S Green, E Oelmann, J S de Bono, M Ranson, U Banerji. *Joint first authors Clin Cancer Res. 2015 Aug 1;21(15):3412-9. doi: 10.1158/1078-0432.CCR-14-2422

“Combining Antiangiogenics to Overcome Resistance: rationale and clinical experience” V Moreno Garcia*, B.Basu*, R Molife, S Kaye. Clinical Cancer Research 2012 Jul 15; 18(14): 3750-61 *Joint first authors

“Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain” B Basu, P Correa-Sampaio, H Mohammed, M Fogarasi, W English, N Watkins, P Corrie, W Ouwehand, G Murphy. International Journal of Biochemistry and Cell Biology 2012 Feb; 44(2): 393-403.