Professor Carlos Caldas

University of Cambridge
Cancer Research UK Cambridge Institute
Department of Oncology
Honorary Academic Clinical Consultant, Head of Breast Cancer Translational Research Unit

Position: Professor
Personal home page: http://www.cruk.cam.ac.uk/research-groups/caldas-group
Email:   Carlos.Caldas@cruk.cam.ac.uk

PubMed journal articles - click here

Professor Carlos Caldas is pleased to consider applications from prospective PhD students.

Research description

BREAST CANCER FUNCTIONAL GENOMICS The molecular taxonomy of breast cancers has revealed a complexity that suggests that different cancers have different cells of origin. The identification and characterisation of these cancer stem cells and their disrupted pathways is one of our research priorities. In parallel we will continue to prospectively validate prognostic and predictive signatures and therapeutic targets with the aim of clinical application.

Research Programme
Breast Cancer

Key publications

Naderi A, Teschendorff AE, Beigel J, Cariati M, Ellis IO, Brenton JD, and Caldas C (2007). Bex2 is overexpressed in a subset of primary breast cancers and mediates NGF/NF-kB inhibition of apoptosis in breast cancer cell lines. Cancer Research 67: 6725-6736

Teschendorff AE, Journée M, Absil P-A, Sepulchre R, and Caldas C (2007). Elucidating the altered transcriptional programs in breast cancer using Independent Component Analysis. PLoS Computational Biology, 3(8):e16

Chin S-F, Wang Y, Thorne NP, Teschendorff AE, Pinder SE, Vias M, Naderi A, Roberts I, Barbosa-Morais NL, Garcia MJ, Iyer NG, Kranjac T, Robertson JFR, Aparicio S, Tavaré S, Ellis IO, Brenton JD, and Caldas C (2007). Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers. Oncogene, 26: 1959-1970