Dr Christine Farr
Dr Christine Farr is pleased to consider applications from prospective PhD students.
I am interested in chromosome biology and the relationship between the structural organisation of vertebrate chromosomes and their function. Previously we have derived a minimal human chromosome, studied de novo telomere formation and genetically manipulated cultured vertebrate cells in order to study various chromosomally-associated proteins, such as the TTAGGG repeat binding factor TRF1 and Topoisomerase II (alpha and beta). Current research focuses on (i) the functional organisation of vertebrate centromere domains; (ii) the role of toposiomerase II at the centromere; (iii) the influence of SUMOylation on its activity; and (iv) topoisomerase II and the Catenation Checkpoint. Our studies combine vertebrate somatic cell genetics with cell biology techniques.
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Johnson M, Phua HH, Bennett SC, Spence JM, Farr CJ (2009) Studying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells. Nucl. Acids Res. 37: e98. Cooley C, Baird KM, Faure V, Wenner T, Stewart JL, Modino S, Slijepcevic P, Farr CJ, Morrison CG (2009) Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells. Mol. Biol. Cell 20: 2563-2571. Spence JM, Phua HH, Mills W, Carpenter AJ, Porter ACG, Farr CJ (2007) Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads. J Cell Sci 120: 3952-3964.