Professor David Rubinsztein

University departments
Department of Medical Genetics
University institutes
Cambridge Institute for Medical Research

Position: Professor
Personal home page:

PubMed journal articles - click here

Professor David Rubinsztein is pleased to consider applications from prospective PhD students.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Methods and technologies
Cell culture
Confocal microscopy
Fluorescence microscopy
Model organisms
Tumour type interests


Recent publications:
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Key publications

VI Korolchuk, S Saiki, M Lichtenberg, FH Siddiqi, EA Roberts, S Imarisio, L Jahreiss, S Sarkar, M Futter, FM Menzies, CJ O’Kane, V Deretic and DC Rubinsztein (2011) Lysosomal positioning coordinates cellular nutrient responses. Nature Cell Biology 13:453-460

S Sarkar, VI Korolchuk, M Renna, S Imarisio, A Fleming, A Williams, M Garcia-Arencibia, C Rose, S Luo, BR Underwood, G Kroemer, CJ O’Kane, and DC Rubinsztein (2011) Complex inhibitory effects of nitric oxide on autophagy. Molecular Cell 43:19-32

K Moreau, B Ravikumar, M Renna, C Puri, and DC Rubinsztein (2011) Autophagosome precursor maturation requires homotypic fusion. Cell 146:303-317

S Luo, M Garcia-Arencibia, R Zhao, C Puri, PPC Toh, O Sadiq and DC Rubinsztein (2012) Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Molecular Cell 47:359-370

C Puri, M Renna, C Figueira Bento, K Moreau and DC Rubinsztein (2013) Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell 154: 1285-1299

M Vicinanza, VI Korolchuk, A Ashkenazi, C Puri, FM Menzies, JH Clarke, DC Rubinsztein (2015) PI(5)P regulates autophagosome biogenesis. Molecular Cell 57:219-234.

A Ashkenazi, CF Bento, T Ricketts, M Vicinanza, F Siddiqi, M Pavel, F Squitieri, MC Hardenberg, S Imarisio, FM Menzies & DC Rubinsztein (2017) Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature 545:108-111