Dr David Fairen-Jimenez
Dr David Fairen-Jimenez is pleased to consider applications from prospective PhD students.
Our research concerns the study of the molecular mechanisms that control adsorption processes in porous materials. We are particularly interested in drug delivery systems, where nanotechnology has a fundamental impact to revolutionise cancer diagnosis and therapy. Our objective is to evaluate new strategies in the study of adsorption processes, the study and design of new porous materials such as metal-organic frameworks (MOFs) and to develop new methods in the prediction of their performance.
The huge development of computational power allows us to use computational simulation, such as grand canonical Monte Carlo (GCMC) and molecular dynamics (MD), and machine learning to design new materials. Nowadays, we run high-throughput screening (HTS) in databases with thousands of materials to find optimal ones for specific applications. Using big data analysis, we can understand how materials properties affect their final performance, whereas using machine learning we can recognise these relationships and discover hidden insights, extrapolating the behaviour towards optimal systems. Once an optimal material is identified, we experimentally engineer and adapt it to the real world and final applications, such as drug delivery.
Symplectic Elements feed provided by Research Information, University of Cambridge
- Design of a Functionalized Metal–Organic Framework System for Enhanced Targeted Delivery to Mitochondria. https://pubs.acs.org/doi/abs/10.1021/jacs.0c00188
- A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown. https://www.sciencedirect.com/science/article/abs/pii/S2451929419303845