Dr David Fernandez-Antoran
Position: Group Leader
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PubMed journal articles - click here
Dr David Fernandez-Antoran is pleased to consider applications from prospective PhD students.
We use long-term human and mouse 3D primary epithelial cultures, in vivo cell lineage tracing, mathematical modelling, next generation sequencing methods and state-of-the-art confocal microscopy techniques to unravel the molecular responses and the cellular interactions that control normal and mutant cell behaviours after exposure to different doses of ionising radiation.
The final aim of our research is to understand the effects of ionising radiation in tumours and normal tissues and set the basis for designing external interventions that can modulate cell competition outcomes, eliminate oncogenic mutations from tissues and reduce the risk of cancer initiation and progression.
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- Colom et al. Mutant clones in normal epithelium outcompete and eliminate emerging tumours. Nature 598, 510–514 (2021). https://doi.org/10.1038/s41586-021-03965-7
- Fowler et al. Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site.
- Piedrafita et al (2020) A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice. Nature Communications doi.org/10.1038/s41467-020-15258-0
- Fernandez-Antoran et al (2019) Outcompeting p53-mutant cells in the normal esophagus by redox manipulation. Cell Stem Cell doi.org/10.1016/j.stem.2019.06.011
