Dr David Noble

Cambridge University Hospitals NHS Foundation Trust

University departments
Department of Oncology

Position: Clinical Research Associate
Personal home page: www.comprt.org

PubMed journal articles - click here

Research description

We aim to develop a dynamic model of the anatomy of head and neck cancer patients undergoing curative radiotherapy. This model will permit calculation of delivered radiation dose and a better understanding of toxicity outcomes. It will also predict future changes in both organs at risk and the tumour in the move towards increasingly adaptive and individualised radiotherapy.

Research Programme or Virtual Institute
Advanced Cancer Imaging
Methods and technologies
Magnetic Resonance Imaging (MRI)
Tumour type interests
Recent publications:
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Key publications

Automatic contour propagation using deformable image registration to determine delivered dose to spinal cord in head-and-neck cancer radiotherapy.
Yeap PL, Noble DJ, Harrison K, Bates AM, Burnet NG, Jena R, Romanchikova M, Sutcliffe MPF, Thomas SJ, Barnett GC, Benson RJ, Jefferies SJ, Parker MA.
Phys Med Biol. 2017 Jul 12;62(15):6062-6073.

Highly Conformal Craniospinal Radiotherapy Techniques Can Underdose the Cranial Clinical Target Volume if Leptomeningeal Extension through Skull Base Exit Foramina is not Contoured.
Noble DJ, Ajithkumar T, Lambert J, Gleeson I, Williams MV, Jefferies SJ.
Clin Oncol (R Coll Radiol). 2017 Jul;29(7);439-447

Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy. Shelley LEA, Scaife JE, Romanchikova M, Harrison K, Forman J, Bates AM, Noble DJ, Jena R, Parker MA, Sutcliffe MPF, Thomas SJ, Burnet NG.
Radiother Oncol. 2017 Jun;123(3):466-471.
Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary ‘VoxTox’ research programme.

Burnet NG, Scaife JE, Romanchikova M, Thomas SJ, Bates AM, Wong E, Noble DJ, Shelley LEA, Bond SJ, Forman JR, Hoole ACF, Barnett GC, Brochu FM, Simmons MPD, Jena RJ, Harrison K, Yeap PL, Drew A, Silvester E, Elwood P, Pullen H, Sultana A, Seah SYK, Russell SG, Benson RJ, Rimmer YL, Jefferies SJ, Taku N, Gurnell M, Powlson A, Schönlieb C-B, Cai X, Sutcliffe MPF, Parker MA.
CERN IdeaSquare Journal of Experimental Innovation. 2017;1(1):3-12

Fast imaging employing steady-state acquisition (FIESTA) MRI to investigate cerebrospinal fluid (CSF) within dural reflections of posterior fossa cranial nerves.
Noble DJ, Scoffings D, Ajithkumar T, Williams MV, Jefferies SJ.
Br J Radiol. 2016 Nov;89(1067):20160392.