Dr Daniel Munoz-Espin

University of Cambridge

University departments
Department of Oncology
University institutes
Early Cancer Institute

Position: Senior Research Associate
Personal home page: https://www.munoz-espinlab.com
Email:   dm742@cam.ac.uk

PubMed journal articles - click here

Research description

My group works at the interface between cellular senescence, plasticity and the fundamental processes and mechanisms that lie at the origin of cancer. We are also developing novel tools and nanodevices for cancer early diagnosis and therapy.

For people interested in joining my laboratory, please contact me directly (dm742@cam.ac.uk).

Research Programme or Virtual Institute
Early Cancer Institute
Secondary Programme
Thoracic Cancer
Strategic Resources
CRUK RadNet Cambridge

Lung cancer
Cellular senescence
Cellular plasticity
Cancer stem cells

Recent publications:
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Key publications

1. Haston S, Gonzalez-Gualda E, Morsli, S, Ge J, …, Muñoz-Espín D*, Martinez-Barbera JP*. Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.
Cancer Cell. 2023; 41:1242-1260. https://doi.org/10.1016/j.ccell.2023.05.004 (* Corresponding authors)
Key Advance: Senescent macrophages as key players of the TME in lung cancer initiation and aged lung.

2. Baker AG, Ou H-L, Hartono M, Bistrovic AP, Brown EL, Joseph J, Golinska M, Sanghera C, Gonzalez-Gualda E, Macias D, …, Vernet A, Bohndiek SE, Fruk L*, Muñoz-Espín D*. In vivo monitoring of celular senescence by photoacustic and fluorescence imaging utilizing a nanostructured ornagic probe.
bioRxiv. 2023 doi:https://www.biorxiv.org/content/10.1101/2023.07.12.548691v1
Key Advance: Developing nanostructured probe to detect senescence in vivo by photoacoustic imaging.

3. Gonzalez-Gualda E, Macias D, Morsli, S, …, Muñoz-Espín D*. A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer.
bioRxiv. 2022 doi: https://doi.org/10.1101/2022.08.01.502019. (* Corresponding author)
Key Advance: Proof-of-concept of the strong tumour promoting activities of chemotherapy-induced senescence in lung cancer and in vivo validation of a novel and more effective combination cancer therapy.

4. Gonzalez-Gualda E, Paez-Ribes M, Lozano-Torres B, …, Muñoz-Espín D*. Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
Aging Cell. 2020; 19:e13142. https://doi.org/10.1111/acel.13142 (* Corresponding author)
Key Advance: Design and validation of a novel activatable prodrug with senolytic properties in cancer.

5. Muñoz-Espín D*, Rovira M, …, Serrano M*. A versatile drug delivery system targeting senescent cells.
EMBO Mol Med. 2018; 10:e9355. https://doi.org/10.15252/emmm.201809355 (* Corresponding authors)
Key Advance: Design and validation of novel therapeutic nanocarriers with senolytic properties in cancer.

6. Muñoz-Espín D, Cañamero M, Maraver A, Gómez-López G, Contreras J, Murillo-Cuesta S, Rodríguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M. Programmed cell senescence during mammalian embryonic development.
Cell. 2013; 155:1104-18. https://doi.org/10.1016/j.cell.2013.10.019 Highly Cited Research Article: 863 citations
Key Advance: Developmental Senescence plays a key role in tissue remodelling in the embryo.

7. Muñoz-Espín D and Serrano M. Cellular senescence: from physiology to pathology.
Nat Rev Mol Cell Biol. 2014; 15:482-496. https://doi.org/10.1038/nrm3823 Highly Cited Review Article: 1610 citations.

Comments on my Publications in Top Journals

• Our paper published in Cancer Cell (Haston et al. 2023) as corresponding author has been commented in:

1. Zhou L and Ruscetti M. Senescent macrophages: A new “old” player in lung cancer development.
Cancer Cell. 2023. https://doi.org/10.1016/j.ccell.2023.05.008
2. Walters H. Senescent macrophages drive lung cancer and accumulate in aging.
Nature Aging. 2023. https://doi.org/10.1038/s43587-023-00459-1
3. Sliker B. Senescent macrophages promote KRAS-driven lung tumorigenesis.
Cancer Discovery. 2023. https://doi.org/10.1158/2159-8290.CD-RW2023-092

• Our paper published in Cell (Munoz-Espin et al. 2013) as first author has been commented in:

1. Campisi J. Cell biology: the beginning of the end.
Nature. 2014;505:35-36. https://doi.org/10.1038/nature12844
2. Banito A, Lowe SW. A new development in senescence.
Cell. 2013;155:977-978. https://doi.org/10.1016/j.cell.2013.10.050
3. Baumann K. Developmentally programmed senescence.
Nat Rev Mol Cell Biol. 2013;15:4. https://doi.org/10.1038/nrm3731
4. Pérez-Garijo A, Steller H. The benefits of aging: cellular senescence in normal development.
EMBO J. 2014;33:99-100. https://doi.org/10.1002/embj.201387401