Dr Daniel Barnes

University of Cambridge

University departments
Department of Public Health and Primary Care

Position: Research Associate
Personal home page: http://www.phpc.cam.ac.uk/people/centre-for-cancer-genetic-epidemiology-people/ccge-research-staff/daniel-barnes/
Email:   drb54@medschl.cam.ac.uk

PubMed journal articles - click here

Research description

My research focuses on the statistical analyses of BRCA1 and BRCA2 gene mutation carriers, primarily through data obtained by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) consortium. These individuals are at increased risk of breast cancer and ovarian cancer in women, and breast cancer and prostate cancer in men. I am particularly interested in genome-wide association analyses, fine-mapping, polygenic risk score, gene-based and pathway analyses.

Research Programme
Ovarian Cancer
Methods and technologies
Epidemiology
Tumour type interests
Breast
Ovary
Prostate

Key publications

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers
Karoline B Kuchenbaecker, John L Hopper, Daniel R Barnes et al Journal of the American Medical Association 2017; 317(23):2402-2416

Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations Daniel R Barnes, Andrew Lee, EMBRACE Investigators, kConFab Investigators, Douglas F Easton and Antonis C Antoniou , Genetic Epidemiology Vol 36(3):274-291

Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers Daniel R Barnes and Antonis C Antoniou, Journal of Internal Medicine Vol 271(4):331-343