Professor Daniel St Johnston
Professor Daniel St Johnston is pleased to consider applications from prospective PhD students.
Most tumours arise from epithelial tissues composed of polarised cells that stick together to form sheets, and a loss of polarity is a hallmark of tumours. We investigate how polarity is established in different epithelial tissues in flies and mammals, and analyse the effects of polarity mutations on epithelial organisation.
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Bergstralh, D. T., Lovegrove, H. E. and St Johnston, D. (2015). Lateral adhesion drives reintegration of misplaced cells into epithelial monolayers. Nat. Cell Biol. doi:10.1038/ncb3248
Morais de Sá, E., A. Mukherjee, N. Lowe and D. St Johnston (2014). Slimb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity. Development 141: 2984-2992.
Bergstralh, D.T., H.E. Lovegrove, and D. St Johnston. (2013). Discs large links spindle orientation to apical-basal polarity in Drosophila epithelia. Curr. Biol. 23:1707-1712.
Zhao, T., Graham, O. Raposo A. and St Johnston, D. (2012) Growing microtubules push the oocyte nucleus to polarize the Drosophila dorsal-ventral axis. Science, 336, 999-1003.
Morais de Sa, E., Mirouse, V. and St Johnston D. (2010) aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. . Cell, 141, 509-523