Professor Daniel St Johnston

University of Cambridge

University departments
Department of Genetics
University institutes
Wellcome Trust CRUK Gurdon Institute

Position: Director of the gurdon Institute
Personal home page: http://www.gurdon.cam.ac.uk/research/stjohnston

PubMed journal articles - click here

Professor Daniel St Johnston is pleased to consider applications from prospective PhD students.

Research description

Most tumours arise from epithelial tissues composed of polarised cells that stick together to form sheets, and a loss of polarity is a hallmark of tumours. We investigate how polarity is established in different epithelial tissues in flies and mammals, and analyse the effects of polarity mutations on epithelial organisation.

Research Programme
Cell and Molecular Biology
Methods and technologies
Confocal microscopy
Fluorescence microscopy
In situ hybridization
In vivo modelling
Microscopy
Model organisms
Protein biochemistry
Proteomics
RNAi
ds139
Recent publications:
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Key publications

Bergstralh, D. T., Lovegrove, H. E. and St Johnston, D. (2015). Lateral adhesion drives reintegration of misplaced cells into epithelial monolayers. Nat. Cell Biol. doi:10.1038/ncb3248
Morais de Sá, E., A. Mukherjee, N. Lowe and D. St Johnston (2014). Slimb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity. Development 141: 2984-2992.
Bergstralh, D.T., H.E. Lovegrove, and D. St Johnston. (2013). Discs large links spindle orientation to apical-basal polarity in Drosophila epithelia. Curr. Biol. 23:1707-1712.
Zhao, T., Graham, O. Raposo A. and St Johnston, D. (2012) Growing microtubules push the oocyte nucleus to polarize the Drosophila dorsal-ventral axis. Science, 336, 999-1003.
Morais de Sa, E., Mirouse, V. and St Johnston D. (2010) aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. . Cell, 141, 509-523

A Drosophila egg chamber showing a large clone of mutant epithelial cells marked by the loss of GFP (green) that cannot reintegrate into the monolayer after they have divided with the wrong orientation.