Professor Elizabeth Murchison

University of Cambridge

University departments
Department of Veterinary Medicine

Position: Professor
Personal home page: http://www.tcg.vet.cam.ac.uk

PubMed journal articles - click here

Professor Elizabeth Murchison is pleased to consider applications from prospective PhD students.

Research description

Elizabeth Murchison studies the genetics and evolution of clonally transmissible cancers. Transmissible cancers are unusual cancers that have survived beyond the bodies of their original hosts via the transmission of living cancer cells. Naturally occurring transmissible cancers are known only in dogs, Tasmanian devils and bivalves. Elizabeth Murchison leads the Transmissible Cancer Group, which particularly studies the genetics and evolution of transmissible cancers in dogs and Tasmanian devils.

Research Programme
Cell and Molecular Biology
Methods and technologies
Bioinformatics
DNA sequencing
Genomics
Tumour type interests
Other
Keywords

Transmissible cancer; contagious cancer

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Key publications

Strakova A, Ni Leathlobhair M, Wang G-D, Yin T-T, Airikkala-Otter I, Allen JL, Allum KM, Bansse-Issa L, Bisson JL, Castillo Domracheva A, de Castro KF, Corrigan AM, Cran HR, Crawford JT, Cutter SM, Delgadillo Keenan L, Donelan EM, Faramade IA, Flores Reynoso E, Fotopoulou E, Fruean SN, Gallardo-Arrieta F, Glebova O, Häfelin Manrique RF, Henriques JJGP, Ignatenko N, Koenig D, Lanza-Perea M, Lobetti R, Lopez Quintana AM, Losfelt T, Marino G, Martincorena I, Martínez Castañeda S, Martínez-López MF, Meyer M, Nakanwagi B, De Nardi AB, Neunzig W, Nixon SJ, Onsare MM, Ortega-Pacheco A, Peleteiro MC, Pye RJ, Reece JF, Rojas Gutierrez J, Sadia H, Schmeling SK, Shamanova O, Ssuna RK, Steenland-Smit AE, Svitich A, Thoya Ngoka I, Vițălaru BA, de Vos AP, de Vos JP, Walkinton O, Wedge DC, Wehrle-Martinez AS, van der Wel MG, Widdowson SAE and Murchison EP 2016 Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer. eLife. 17 May 2016; DOI: 10.7554/eLife.14552

Pye RJ, Pemberton D, Tovar C, Tubio JMC, Dun KA, Fox S, Darby J, Hayes D, Knowles GW, Kreiss A, Siddle HVT, Swift K, Lyons AB, Murchison EP, Woods GM 2016 A second transmissible cancer in Tasmanian devils. PNAS. 113(2): p. 374-9.

Strakova A and Murchison EP 2015 The cancer which survived: insights from the genome of an 11,000 year-old cancer. Current Opinion in Genetics and Development. 30:49-55

Murchison EP, Wedge DC §, Alexandrov LB, Fu, B, Martincorena I, Ning Z, Tubio JMC, Werner EI, Allen J, Barboza de Nardi A, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR* 2014 Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage. Science. Jan 24;343(6169):437-40

Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ, Fu B, Hims M, Ding Z, Ivakhno S, Stewart C, Ng BL, Wong W, Aken B, Alsop A, Becq J, Bignell GR, Cheetham RK, Cheng W, Connor TR, Cox AJ, Feng Z, Gu Y, Grocock RJ, Harris SR, Khrebtukova I, Kingsbury Z, Kowarsky M, Kreiss A, Luo S,  Marshall J, McBride DJ, Murray L, Pearse AM, Raine K, Rasolonjatovo I, Shaw R, Tedder P, Tregidgo C, White S, Woods GM, Gormley N, Humphray S, Schroth G, Smith G, Hall K, Searle S, Carter N, Papenfuss AT, Futreal PA, Campbell P, Yang F, Bentley DR, Evers DJ and Stratton MR (2012) Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer. Cell. Feb 17;148(4):780-91

Murchison EP, Tovar C, Hsu A, Bender HS, Kheradpour P, Rebbeck C, Obendorf D, Conlan C, Bahlo M, Blizzard C, Pyecroft S, Kreiss A, Kellis M, Stark A, Harkins TT, Graves JAM, Woods GM, Hannon GJ and Papenfuss AT (2010) The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer. Science. Jan 1 327(5961):84-7

Murchison EP (2009) Clonally transmissible cancers in dogs and Tasmanian devils. Oncogene 27: S19 ? S30.

Free-roaming dogs in Australia. Image courtesy of AMRRIC.