Dr Folma Buss

University of Cambridge

University departments
Department of Clinical Biochemistry
University institutes
Cambridge Institute for Medical Research

Position: Reader
Personal home page:
Email:   Public email address:  fb207@cam.ac.uk

PubMed journal articles - click here

Dr Folma Buss is pleased to consider applications from prospective PhD students.

Research description

Our work aims to determine of the cellular role(s) of myosin motor proteins in intracellular transport processes, cell signaling and membrane dynamics, and how defects in these molecular machines are linked to cancer, neurodegeneration and inflammation. Myosins are molecular motors that produce force and movement along actin filament tracks powered by ATP. The human genome contains 39 myosin genes that can be grouped into 12 different classes. Most cell types express multiple myosins - at least 12 different myosins belonging to 8 different classes- each with a distinct cellular function in cell migration, vesicle transport, regulation of actin organization and cytokinesis. Currently one of our main objectives is to understand the mechanisms that regulate motor activity and the process of cargo selection and to identify the interactome of different classes of myosin motors using functional proteomics.

Research Programme
Cell and Molecular Biology
Methods and technologies
Cell culture
Confocal microscopy
Fluorescence microscopy
Imaging
Immunohistochemistry
Microscopy
Optical traps
Protein biochemistry
Protein purification
Proteomics
Recombinant protein expression
RNAi
Tumour type interests
Breast
Ovary
Prostate
Keywords
myosin
actin
cell migration
signaling
fb207
Recent publications:
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Key publications

1. Masters TA, Tumbarello DA, Chibalina, M and Buss F. Myosin VI co-ordinates Akt activation and actin reorganisation by regulating signalling endosome position and function. (2017). Cell Reports 19(10): 2088-2101.
2. Masters TA and Buss F. Filopodia formation induced by a Myosin VI mutant that moves towards the plus end of actin filaments. (2017) PNAS 114(7):1595-1600.
3. Tumbarello DA, Waxse BJ, Arden SD, Bright NA, Kendrick-Jones J, Buss F Autophagy-receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. (2012) Nature Cell Biology 10: 1024-35.
4. Brandstaetter H, Kendrick-Jones J, Buss F Myo1c regulates lipid raft recycling to control cell spreading, migration and Salmonella invasion (2012) J Cell Sci., 125, 1991-2003.

MYO6 regulates localisation of APPL1-positive signaling endosomes to actin filaments in the cell cortex.