Dr Franklin Aigbirhio

Cambridge University Hospitals NHS Foundation Trust

University departments
Department of Clinical Neuroscience
University institutes
Cambridge Institute for Medical Research
NHS or other affiliations
Wolfson Brain Imaging Centre

Position: Director of PET Chemistry
Personal home page: http://www.wbic.cam.ac.uk

PubMed journal articles - click here

Dr Franklin Aigbirhio is pleased to consider applications from prospective PhD students.

Research description

Research in the development and application of molecular imaging probes, in particular for the in vivo imaging technique of positron emission tomography. Objectives are to design, develop and apply imaging probes that are specific and selective to biological markers and are sensitivity to biochemical changes associated with disease mechanisms. In addition we research novel radiosynthetic methods with an objective of 1) developing rapid and efficient methods for the regular preparation of radiopharmaceuticals and 2) facilitating the discovery of new chemical entities for imaging.

Research Programme
Advanced Cancer Imaging
Keywords
radiochemistry
organic chemistry
fia20
Recent publications:
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Key publications

Burton TJ, Mackenzie IS, et al (2011), Evaluation of the Sensitivity and Specificity of 11C-Metomidate Positron Emission Tomography (PET)-CT for Lateralizing Aldosterone Secretion by Conn's Adenomas. J Clin Endocrinol Metab. Nov 23. [Epub ahead of print] Pascu SI, Waghorn PA, Kennedy BW, Arrowsmith RL, Bayly SR, Dilworth JR, Christlieb M, Tyrrell RM, Zhong J, Kowalczyk RM, Collison D, Aley PK, Churchill GC, Aigbirhio FI (2010), Fluorescent copper(II) bis(thiosemicarbazonates): synthesis, structures, electron paramagnetic resonance, radiolabeling, in vitro cytotoxicity and confocal fluorescence microscopy studies Chem Asian J (5)506-519. Price SJ, Fryer TD, Cleij MC, Dean AF, Joseph J, Salvador R, Wang DD, Hutchinson PJ, Clark JC, Burnet NG, Pickard JD, Aigbirhio FI, Gillard JH.(2009) Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study. Clin Radiol (64) 52-63

In vivo Imaging : MRI and PET using [18F]FLT of a glioblastoma brain tumour