Professor Florian Markowetz

University of Cambridge

University departments
Cancer Research UK Cambridge Institute

Position: Group Leader
Personal home page:

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Professor Florian Markowetz is pleased to consider applications from prospective PhD students.

Research description

We develop computational approaches for the systems genetics of cancer. To identify drivers of cancer we link genetic data to molecular and cellular phenotypes. Our work combines two complementary directions by (1) analyzing global portraits of cancer and (2) modeling key mechanisms and their response to perturbations.

Research Programme or Virtual Institute
Ovarian Cancer
Methods and technologies
Computational modelling
DNA sequencing
Gene expression profiling
Statistical analysis
Tumour type interests
Brain and central nervous system
Recent publications:
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Key publications

E.M. Ross and F. Markowetz (2016) OncoNEM: Inferring tumour evolution from single-cell sequencing data. Genome Biology 2016, 17:69

K. Yuan et al (2015) BitPhylogeny: A probabilistic framework for reconstructing intra-tumor phylogenies. Genome Biology, 2015, 16:36

Schwarz et al (2015) Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic reconstruction. PLoS Medicine, 2015 Feb 24;12(2):e1001789.

The Markowetz lab research areas