Dr Florian Markowetz

University of Cambridge
Cancer Research UK Cambridge Institute

Position: Group Leader
Personal home page: http://www.markowetzlab.org

PubMed journal articles - click here

Dr Florian Markowetz is pleased to consider applications from prospective PhD students.

Research description

We develop computational approaches for the systems genetics of cancer. To identify drivers of cancer we link genetic data to molecular and cellular phenotypes. Our work combines two complementary directions by (1) analyzing global portraits of cancer and (2) modeling key mechanisms and their response to perturbations.

Research Programme
Ovarian Cancer
Methods and technologies
Bioinformatics
Computational modelling
DNA sequencing
Gene expression profiling
Genomics
Imaging
Immunohistochemistry
Statistical analysis
Tumour type interests
Brain and central nervous system
Breast
Ovary
Pancreas
Prostate

Key publications

E.M. Ross and F. Markowetz (2016) OncoNEM: Inferring tumour evolution from single-cell sequencing data. Genome Biology 2016, 17:69

K. Yuan et al (2015) BitPhylogeny: A probabilistic framework for reconstructing intra-tumor phylogenies. Genome Biology, 2015, 16:36

Schwarz et al (2015) Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic reconstruction. PLoS Medicine, 2015 Feb 24;12(2):e1001789.

The Markowetz lab research areas