Professor Guy Brown

University of Cambridge

University departments
Department of Biochemistry

Position: Professor
Personal home page: www.guybrown.net

PubMed journal articles - click here

Professor Guy Brown is pleased to consider applications from prospective PhD students.

Research description

(i) Inflammatory neurodegeneration in the brain. (ii) Mitochondria, nitric oxide & cell death. (iii) Cell death in leukaemia.

Research Programme
Neuro-Oncology
Keywords
Phagocytosis
Phagoptosis
Cell death
gcb3
Recent publications:
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Key publications

Hornik TC, Neniskyte U & Brown GC (2013) Inflammation induces Multinucleation of Microglia via PKC inhibition of Cytokinesis, generating highly phagocytic Multinucleated Giant Cells. J. Neurochem. In press Neher JJ, Emmrich JV, Fricker M, Mander PK, Thery C, Brown GC (2013) Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci 110:E4098-107. Fricker M, Vilalta A, Tolkovsky AM, Brown GC (2013) Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia. J Biol Chem. 288, 9145-52. Borutaite V, Toleikis A, Brown GC (2013) In the eye of the storm: mitochondrial damage during heart and brain ischaemia. FEBS J. 280:4999-5014. Fricker M, Oliva-Martin MJ, Brown GC (2012) Primary phagocytosis of viable neurons by microglia activated with LPS or Abeta is dependent on calreticulin/LRP phagocytic signalling. Journal of Neuroinflammation, 13, 9. Brown GC & Neher JJ (2012) Eaten alive! Cell death by primary phagocytosis: ?phagoptosis?. Trends Biochem. Sci. 37, 325-332. Fricker M, Neher JJ, Zhao JW, Théry C, Tolkovsky AM, Brown GC (2012) MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation. J Neurosci. 32, 2657-66. Brown GC & Borutaite V (2012) There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells. Mitochondrion 12, 1-4. Neniskyte U, Neher JJ, Brown GC. (2011) Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia. J Biol Chem. 286:39904-13. Neher JJ, Neniskyte U, Zhao ZW, Bal-Price A, Tolkovsky AM & Brown GC (2011) Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J. Immunol. 186, 4973-83. Brown RD, Burke GA, Brown GC (2009) Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine. Free Radic Biol Med. 46:1211-20.