Professor Gillian Murphy
Position: Emeritus Professor Senior Visitor Dept of Oncology
Personal home page: http://science/cancerresearchuk.org/research/loc/cambridge/ccri/murphyg
PubMed journal articles - click here
The Murphy Group studied cell surface proteinases that modulate both the extracellular matrix and the activities of key cytokines and growth factors and have generated information on their structure function relationships that are key to the understanding of their role in biology and pathology and the design of novel therapeutic approaches to cancer. These enzymes are located on both tumour and interacting stromal cells and are regulated by trafficking which allows specific localisation in events such as cell invasion. The identification of the importance of specific enzyme domains has also generated novel ideas for the production of novel inhibitors.
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Lee MH, Rapti M, Murphy G. (2005) Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: Fine-tuning TIMP-4 for optimal inhibition of TNF-a converting enzyme (TACE). J Biol Chem., 280(16):15967-75 Wallard MJ, Pennington CJ, Veerakumarasivam A, Burtt G, Mills IG, Warren A, Leung HY, Murphy G, Edwards DR, Neal DE, Kelly JD. (2006) Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma. Br J Cancer. 94:569-77. Krubasik D, Eisenach PA, Kunz-Schughart LA, Murphy G, English WR (2007) Granulocyte-Macrophage Colony Stimulating Factor induces endothelial capillary formation through induction of matrix type1-metalloproteinase expression in vitro. Int J Cancer, in press