Professor George Vassiliou

Wellcome Trust Sanger Institute
University of Cambridge

University departments
Department of Haematology
University institutes
Wellcome Trust MRC Cambridge Stem Cell Institute
NHS or other affiliations
Haematological Cancer Genetics Group

Position: Professor
Personal home page:

PubMed journal articles - click here

Professor George Vassiliou is pleased to consider applications from prospective PhD students.

Research description

I am a CR-UK Senior Clinical Fellow and a member of Faculty at the Wellcome Sanger and Wellcome-MRC Cambridge Stem Cell Institutes. My group is studying the pre-clinical evolution, pathogenesis and treatment of haematological malignancies with a particular focus on acute myeloid leukaemia (AML). I am also a Consultant Haematologist at Addenbrooke's Hospital in Cambridge where I treat patients with haematological cancers.

Research Programme or Virtual Institute
Haematological Malignancies Virtual Institute
Methods and technologies
Cell culture
DNA sequencing
Gene expression profiling
Model organisms
Tumour type interests
Clonal Haematopoiesis
CRISPR screens
Clonal evolution
Acute Myeloid Leukaemia
Myeloid Malignancies
Recent publications:
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Key publications

Tzelepis K, et al. SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Nature Communications, 9, 5378, doi:10.1038/s41467-018-07620-0 (2018).

Abelson S, Collord G, et al. Prediction of acute myeloid leukaemia risk in healthy individuals. Nature 559, 400-404, doi:10.1038/s41586-018-0317-6 (2018).

Gozdecka M, et al. UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nature Genetics, doi:10.1038/s41588-018-0114-z (2018).

Barbieri I, Tzelepis K, et al. Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control. Nature 552, 126-131, doi:10.1038/nature24678 (2017).

Dovey OM, et al. Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia. Blood 130, 1911-1922, doi:10.1182/blood-2017-01-760595 (2017).

Mupo A, et al. Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia
without ring sideroblasts. Leukemia 31, 720-727, doi:10.1038/leu.2016.251 (2017).

Tzelepis K, et al. A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia. Cell Reports, 17, 1193-1205, doi:10.1016/j.celrep.2016.09.079 (2016).

McKerrell T, et al. Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies. Blood, doi:10.1182/blood-2015-11-683334 (2016).

McKerrell T, et al. Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Reports 10, 1239-1245, doi:10.1016/j.celrep.2015.02.005 (2015).

Vassiliou G, et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nature Genetics, 43(5):470-5, doi: 10.1038/ng.796 (2011).