Dr Harry Bulstrode

Cambridge University Hospitals NHS Foundation Trust
Department of Clinical Neuroscience

Position: Clinical Lecturer
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PubMed journal articles - click here

Research description

I have recently secured a CRUK Pioneer Award to fund my research into oncolytic virus therapies specific to the glioma stem cell population.

I hold an Academic Clinical Lecturer post in Neurosurgery at the University of Cambridge, combining clinical training at Addenbrooke's Hospital with research interests in the biology of glioma and technologies for improving surgical resection of these tumours.

Research Programme
Neurobiology and Brain Cancers
Methods and technologies
Bioinformatics
Cell culture
Clinical trials
Fluorescence microscopy
Gene expression profiling
Genomics
Immunohistochemistry
Model organisms
PCR
Tumour type interests
Brain and central nervous system

Key publications

1. Bulstrode H, Johnstone E, Marques-Torrejon MA, Ferguson KM, Bressan RB, Blin C, Grant V, Gogolok S, Gangoso E, Gagrica S, Ender C, Fotaki V, Sproul D, Bertone P, Pollard SM. Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators. Genes & Development (in press)

2. Bulstrode H, Kabwama S, Durnford A, Hempenstall J, Chakraborty A. Temporising extradural haematoma by craniostomy using an intraosseous needle Injury 2017 Feb 20. pii: S0020-1383(17)30082-7.

3. Bressan RB, Dewari PS, Kalantzaki M, Gangoso E, Matjusaitis M, Garcia-Diaz C, Blin C, Grant V, Bulstrode H, Gogolok S, Skarnes WC, Pollard SM. Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells Development 2017 Feb 15;144(4): 635-648.

4. Siney EJ, Holden A, Casselden E, Bulstrode H, Thomas GJ, Willaime-Morawek S. Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells Mol Neurobiol 2016 Aug 19

5. Caren H, Stricker SH, Bulstrode H, Gagrica S, Johnstone E, Bartlett T, Feber, A, Wilson G, Teschendorff A, Bertone P, Beck S, Pollard S. Glioblastoma stem cells respond to differentiation cues but fail to undergo differentiation commitment and terminal cell cycle arrest Stem Cell Reports 2015 Oct 21. pii: S2213-6711(15)00276-3

6. Stewart SK, Morris TJ, Guilhamon P, Bulstrode H, Bachman M, Balasubramanian S, Beck S. oxBS-450K: a method for analysing hydroxymethylation using 450K BeadChips. Methods 2015 Jan 15: 72: 9-15

7. Bulstrode H, Nicoll JA, Hudson G, Chinnery PF, Di Pietro V, Belli A. Mitochondrial DNA and Traumatic Brain Injury. Annals of Neurology 2014 Feb:75(2):186-95

8. Bulstrode H, Jones LM, Siney EJ, Sampson JM, Ludwig A, Gray WP, Willaime-Morawek S. A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumour sphere forming cells. Cancer Letters 2012 Dec 29;326(1):79-87

9. Willmore BDB, Bulstrode H, Tolhurst DJ. Contrast normalization contributes to a biologically-plausible model of receptive field development in primary visual cortex (V1). Vision Research 2012 Feb 1;54:49-60.