Dr Hayley Sharpe

Babraham Institute

Position: Principal Investigator
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PubMed journal articles - click here

Dr Hayley Sharpe is pleased to consider applications from prospective PhD students.

Research description

Our aim is to understand the function and regulation of receptor tyrosine phosphatases in vivo using proteomics, cell biology and mouse models.
The reversible phosphorylation of tyrosine residues on proteins serves as a critical switch in the regulation of fundamental cellular processes and is controlled by the antagonistic actions of protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Dysregulation of this balance is associated with numerous diseases such as cancer as well as developmental abnormalities. Our main objectives are to understand mechanisms of cell signalling that are mediated by the membrane-associated receptor PTPs (RPTPs) by identifying their physiological roles, substrates and principles of regulation.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Recent publications:
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