Dr Isidro Cortes Ciriano

European Bioinformatics Institute

Position: Group Leader
Personal home page: https://www.ebi.ac.uk/research/cortes-ciriano
Email:   Public email address:  icortes@ebi.ac.uk

PubMed journal articles - click here

Dr Isidro Cortes Ciriano is pleased to consider applications from prospective PhD students.

Research description

We are interested in the development of computational tools to characterize the patterns of mutations and genome instability processes in human cancers through the analysis of genome sequencing data from clinical samples and preclinical models. Our research areas include the discovery of biomarkers of drug response, inference of the molecular mechanisms underlying cancer evolution, early detection of cancer, and the identification of the somatic alterations predictive of response and resistance to immunotherapies. We are also interested in the application of artificial intelligence to model drug response using genomically characterized preclinical models to uncover new vulnerabilities of cancer.

Research Programme
Early Detection
Methods and technologies
Bioinformatics
Computational modelling
DNA sequencing
Genomics
Statistical analysis
Tumour type interests
Bladder
Bone and connective tissue
Brain and central nervous system
Breast
Colorectal
Liver
Lung
Melanoma
Oesophagus
Oral
Ovary
Pancreas
Stomach
Keywords
cancer genomics
computational biology
whole-genome sequencing
early detection
immunotherapy
drug discovery

Key publications

Selected publications (full list at https://www.ebi.ac.uk/research/cortes-ciriano)
Cortes-Ciriano, I. et al. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. bioRxiv 333617. Nat. Genet. In press (2019).
Cortes-Ciriano, I., Lee, S., Park, W.-Y., Kim, T.-M. & Park, P. J. A molecular portrait of microsatellite instability across multiple cancers. Nat. Commun. 8, 15180 (2017).