Professor Ian Paterson

University of Cambridge
Department of Chemistry

Position: Professor
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PubMed journal articles - click here

Research description

Organic synthesis - generally related to anticancer natural products and analogues. Synthesis of potent cytotoxic payloads for antibody-drug conjugates. See our website for examples.

Research Programme
Recent publications:
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Key publications

[1] Dalby, S. M.; Goodwin-Tindall, J.; Paterson, I. Total synthesis of (?)-rhizopodin. Angew. Chem. Int. Ed. 2013, 52, 6517?6121. doi: 10.1002/anie.201301978 [2] Paterson, I.; Fink, S. J.; Lee, L. Y. W.; Atkinson, S. J.; Blakey, S. B. Total synthesis of aplyronine C. Org. Lett. 2013, 15, 3118?3121. doi: 10.1021/ol401327r [3] Paterson, I.; Maltas, P.; Dalby, S. M.; Lim, J. H.; Anderson, E. A. A second-generation total synthesis of spirastrellolide A methyl ester. Angew. Chem. Int. Ed. 2012, 51, 2749?2753. doi: 10.1002/anie.201108594 [4] Paterson, I.; Dalby, S. M.; Roberts, J. C.; Naylor, G. J.; Guzman, E. A.; Isbruker, R.; Pitts, T. P.; Linley, P.; Divlianska, D.; Reed, J. K.; Wright, A. E. Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp. Angew. Chem. Int. Ed. 2011, 50, 3219?3223. Hot Paper. doi: 10.1002/anie.201007719 [5] Paterson, I.; Naylor, G. J.; Gardner, N. M.; Guzman, E.; Wright, A. E. Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol. Chem. Asian J. 2011, 6, 459?473. doi: 10.1002/asia.201000541