Professor Julie Ahringer
Professor Julie Ahringer is pleased to consider applications from prospective PhD students.
We investigate the functions chromatin regulatory complexes implicated in human disease using the C. elegans model system. These include the histone deacetylase complex NuRD, the Retinoblastoma complex DRM, and a TIP60 histone acetyltransferase complex. We also study the relationship between modification of histones in exonic chromatin and mRNA splicing. The small well-annotated genome, powerful RNAi technology, and rich resource of chromatin mutants of C. elegans make it an excellent system for studies of chromatin function. We address these questions using chromatin immunoprecipitation followed by deep sequencing, global mRNA expression analyses and other genetic and genomic methods combined with bioinformatics.
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Liu, T., et al (2011) Broad chromosomal domains of histone modification patterns in C. elegans, Genome Research, 21: 227-236. Kolasinska-Zwierz, P., Down, T., Latorre, I., Liu, T., Liu, X.S, and Ahringer, J. (2009) Differential chromatin marking of introns and expressed exons by H3K36me3. Nature Genetics, 41, 376-381. Kamath, R.S., Fraser, A.G., Dong, Y., Poulin, G., Durbin, R., Gotta, M., Kanapin, A., Le Bot, N., Moreno, S., Sohrmann, M., Welchman, D., Zipperlen, P., and Ahringer, J. (2003) Systematic Functional Analysis of the C. elegans Genome using RNAi. Nature, 421, 231-237.