Dr James Tysome

Cambridge University Hospitals NHS Foundation Trust

University departments
Department of Surgery

Position: Clinical Consultant
Personal home page: http://www.cuh.org.uk/addenbrookes/services/clinical/skull_base_unit/skull_base_index.html

PubMed journal articles - click here

Dr James Tysome is pleased to consider applications from prospective PhD students.

Research description

Angiogenesis plays a role in the growth of many skull base and head and neck tumours. I aim to investigate the role of angiogenesis inhibitors in these tumours, develop novel inhibitors including oncolytic viruses and use molecular imaging techniques to determine tumour growth rates and response to treatment. I am also interested in the use of hearing implants in patients with neurofibromatosis type 2.

Research Programme or Virtual Institute
Brain Cancer Virtual Institute
Recent publications:
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Key publications

Tysome JR, Li X, Wang S, Wang P, Gao P, Du P, Chen D, Gangeswaran R, Chard L, Yuan M, Alusi G, Lemoine NR. A novel therapeutic regime to eradicate established solid tumors with an effective induction of tumor-specific immunity (2012). Clinical Cancer Research 18(24):6679-89 Tysome JR, Macfarlane R, Durie-Gair J, Donnelly N, Mannion R, Knight R, Harris F, Vanat ZH, Tam YC, Burton K, Hensiek A, Raymond FL, Moffat DA, Axon PR. Surgical management of vestibular schwannomas and hearing rehabilitation in neurofibromatosis type 2 (2012). Otology Neurotology 33(3):466-72 Tysome JR, Wang P, Briat A, Alusi G, Gangeswaran R, Bhakta V, Francis J, Timiryasova T, Fodor I, Lemoine NR, Wang Y. Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: a superior oncolytic virus to dl1520 (ONYX-015) for human head and neck cancer (2011). Human Gene Therapy 22(9):1101-8