Dr Jennifer Gallop
Dr Jennifer Gallop is pleased to consider applications from prospective PhD students.
We are interested in understanding the mechanisms underlying remodelling of the actin cytoskeleton. Force generation by actin polymerisation is important for fundamental cell biological activities such as cell motility, cell shape change, vesicle trafficking, cytokinesis. Alterations in actin-based cell protrusions and movement are a characteristic difference in metastasizing cancer cells compared with normal cells. We use in vitro reconstitution systems, advanced microscopy and model organisms to understand how signalling, proteins and lipids that regulate the actin cytoskeleton orchestrate actin dynamics.
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Lee K*, Gallop JL*, Rambani K and Kirschner MW (2010) Self-assembly of filopodia-like structures on supported lipid bilayers. Science 329: 1341-1345 Gallop JL*, Jao CC*, Kent HM, Butler PJ, Evans PR, Langen R and McMahon HT (2006) Mechanism of endophilin N-BAR domain-mediated membrane curvature. EMBO J 25: 2898-2910 McMahon HT and Gallop JL (2005) Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature 438: 590-596