Dr Konstantinos Tzelepis
Our group is uncovering epigenetic mechanisms that are implicated in devastating malignancies including acute myeloid leukaemia (AML). Our work has previously identified several novel RNA-binding/modifying proteins that are essential for AML cell survival, including the RNA methyltransferase METTL3 and the splicing kinase SRPK1. Now, the group is investigating the role of RNA modifications and splicing in cancer initiation and maintenance.
- Yankova, Blackaby et al. Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature 2021
- Orellana et al. METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation. Molecular Cell 2021
- Mikutis et al. meCLICK-Seq – a substrate-hijacking and RNA degradation strategy for the study of RNA methylation. ACS Central Science 2020