Dr Luiza Moore

Wellcome Trust Sanger Institute

University departments
Cancer Research UK Cambridge Institute
University institutes
CRUK Cambridge Institute
NHS or other affiliations
Cambridge University Hospitals NHS Foundation Trust

Position: Clinical Consultant
Personal home page: https://scholar.google.com/citations?hl=en&user=y1mRXAUAAAAJ&view_op=list_works&sortby=pubdate
Email:   lm14@sanger.ac.uk

PubMed journal articles - click here

Research description

Somatic mutation and clonal evolution in normal and cancer cells

Research Programme or Virtual Institute
Early Cancer Institute
Secondary Programme
Ovarian Cancer
Methods and technologies
Tumour type interests
Uterus and unspecified
gynaecological tumours
somatic evolution
molecular pathology
Recent publications:
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Key publications

Moore L*, Cagan A*, Coorens T*, [authors ...] Stratton MR†, Rahbari R† (2021) The landscape of somatic mutations in normal human cells. Nature, 597, 381-386.

Coorens T*,Moore L*, [authors ...] Stratton MR (2021) Extensive phylogenies of normal human development. Nature, 597, 387-392.

Moore L, Leongamornlert D, Coorens T, Sanders MA, Ellis P, Dawson K, Maura F, Nangalia J, Tarpey PS, Brunner SF, Lee-Six H, Rahbari R, Hooks Y, Mahbubani K, Jimenez-Linan M, Brosens JJ, Iacobuzio-Donahue C, Martincorena I, Saeb-Parsy K, Campbell PJ, Stratton MR (2020) The mutational landscape of normal human endometrial epithelium. Nature, 580, 640-646.

Ellis P*, Moore L*, Sanders MA*, Butler TM*, Brunner SF, Lee-Six H, Osborne RJ, Farr B, Lawson ARJ, Cagan A, Stratton MR, Martincorena I, Campbell PJ. Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing. Nature Protocols https://doi.org/10.1038/s41596-020-00437-6


Fu Y, Jung AW, ViñasTorne R, Gonzalez S, Vöhringer H, JimenezLinan M, Moore L*, Gerstung M* (2020) Pan-cancer computational histopathology reveals mutations, tumour composition and prognosis. Nature Cancer, 1, 800-810.

Youd E & Moore L (2020) COVID-19 autopsy in people who died in community settings: the first series. Journal of Clinical Pathology, 6, 1-5.


Williams N, Lee J, Mitchell E, Moore L, [authors ...], Nangalia J (2022) Life histories of myeloproliferative neoplasms inferred from phylogenies. Nature, 602, 162-168.

Garcia-Alonso L, [authors ...], Moore L, Bayraktar OA, Teichman SA, Turco MY, Vento-Tormo R (2021). Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro. Nature Genetics, 53, 1698-1711.

Spencer Chapman M, [authors ...], Moore L, Nangalia J, Robinson P, Yoshida K, Hook E, Campbell PJ, Cvejic A (2021). Lineage tracing of human development through somatic mutations. Nature, 595, 85-90.

Ng SWK, Rouhani FJ, Brunner SF, Brzozwska N, Aitken SJ, Yang M, Abascal F, Moore L, Campbell PJ (2021) Convergent somatic mutations in metabolism genes in chronic liver disease. Nature, 598, 473-478.

Coorens T, Treger TD, Al-Saadi R, Moore L, Tran MGB, Mitchell TJ, Tugnait S, Thevanesan C, Young MD, Oliver TRW, Oostveen M, Collord G, Tarpey PS, Cagan A, Hooks Y, Brougham M, Reynolds BC, Barone G, Anderson J, Jorgensen M, Burke GA, Visser J, Nicholson JC, Smeulders N, Mushtaq I, Stewart GD, Campbell PJ, Martincorena I, Rampling D, Hook L, Warren AY, Coleman N,  Chowdhury T, Sebire N, Drost J, Saeb-Parsy K, Stratton MR, Straathof K, Pritchard-Jones K, Behjati S (2019) Embryonal precursors of childhood kidney cancer. Science, 366, 1247-1251.

Brunner SF, Roberts ND, Wylie LA, Moore L, Aitken SJ, Davies SE, Sanders MA, Ellis P, Alder C, Hooks Y, Abascal F, Stratton MR, Martincorena I, Hoare M, Campbell PJ (2019) Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature, 574, 538-542.

Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, Georgakopoulos N, Torrente F, Noorani A, Goddard M, Robinson R, Coorens T, O’Neill, Alder C, Wang J, Fitzgerald RC, Zilbauer M, Coleman N, Saeb-Parsy K, Martincorena I, Campbell PJ, Stratton MR (2019) The landscape of somatic mutation in normal colorectal epithelial cells. Nature, 574, 532-537.

Lawson ARJ, Abascal F, Coorens THH, Hooks Y, O’Neill L, Latimer C, Raine K, Sanders MA, Warren AY, Mahbubani KTA, Butler TB, Harvey L, Cagan A, Menzies A, Moore L, Colquhoun A, Turner W, Thomas B, Gnanapragasam V, Williams N, Rassl DM, Vöhringer H, Zumalave S, Nangalia J, Tubío JMC, Gerstung M, Saeb-Parsy K, Stratton MR, Campbell PJ, Mitchell TJ, Martincorena I (2020) Somatic mutation and widespread clonal selection in human bladder. Science, 370,  6512, 75-82.

Maura F, Degasperi A, Nadeu F, Leongamornlert D, Davies H, Moore L, Royo R, Ziccheddu B, Puente XS, Avet-Loiseau H, Campbell PJ, Nik-Zainal S, Campo E, Munshi N, Bolli N (2019) A practical guide for mutational signature analysis in hematological malignancies. Nature Communications, 10, 2969.

Rabbie R*, Ansari-Pour N*, Cast O, Lau D, Scott F, Welsh S, Parkinson C, Khoja L, Moore L, Tullett M, Wong K, Ferreira I, Martínez JM, Levesque J, Gallagher F, Jiménez-Sánchez A, Miller M, Riva L, Allinson K, Campbell PJ, Corrie P, Wedge D, Adams DJ (2020) Multisite clonality analyses uncovers pervasive subclonal heterogeneity and branching evolution across melanoma metastases. Nature Communications11, 4306.

Macintyre G, Goranova TE, De Silva D, Ennis D, Piskorz AM, Eldridge M, Sie D, Lewsley LA, Hanif A, Wilson C, Dowson S, Glasspool RM, Lockley M, Brockbank E, Montes A, Walther A, Sundar S, Edmondson R, Hall GD, Clamp A, Gourley C, Hall M, Fotopoulou C, Gabra H, Paul J, Supernat A, Millan D, Bryson G, Nourse C, Mincarelli L, Navarro Sanchez L, lstra BY, Jimenez-Linan M, Moore L, Hofmann O, Markowetz F, McNeish IA, Brenton JD (2018) Copy-number signatures and mutational processes in ovarian carcinoma. Nature Genetics, 50, 1262-1270.