Dr Luca Pellegrini

University of Cambridge

University departments
Department of Biochemistry

Position: Research Fellow
Personal home page: http://www.bioc.cam.ac.uk/uto/pellegrini.html

PubMed journal articles - click here

Dr Luca Pellegrini is pleased to consider applications from prospective PhD students.

Research description

The faithful inheritance of genetic information is essential to cellular life. Successful transmission of the genetic material requires the accurate replication of the genome and the repair of any DNA lesion that might block replication or alter the encoded message. Failure of the complex molecular systems that preserve the integrity of our DNA is a major contributing factor in human disease. The goal of our research is to understand structure and function of the macromolecular assemblies responsible for the maintenance and replication of our genome.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Recent publications:
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Key publications

Klinge S, Hirst J, Maman JD, Krude T, Pellegrini L (2007) An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis, Nat Struct Mol Biol, 14: 875-7. Davies OR & Pellegrini L (2007), Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats, Nat Struct Mol Biol, 14: 475-83. Nookala RK, Hussain S, Pellegrini L (2007), Insights into Fanconi Anaemia from the structure of human FANCE, Nucleic Acids Res 35:1638-48.