My research focus on 1) how immune complexity evolves in Oesophageal adenocarcinoma and its precancerous lesion, Barrett's oesophagus. Using several advanced multiplex imaging technologies and novel computational algorithm Sparse Subspace Coding, we aim to decipher which are the key immune cell populations that involved in the progression of cancer; 2) what and how intrinsic genetic and extrinsic environmental factors initiate and promote the malignant progression from Barrett's oesophagus to Oesophageal adenocarcinoma. We have established multiple lines of in vitro experimental models to answer these questions.