Dr Marc Fiedler

MRC Laboratory of Molecular Biology

NHS or other affiliations
Protein and Nucleic Acid Chemistry (PNAC)

Position: Senior Research Associate
Personal home page: http://www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/mariann-bienz/

PubMed journal articles - click here

Dr Marc Fiedler is pleased to consider applications from prospective PhD students.

Research description

Structural and functional analysis of Wnt pathway components

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Methods and technologies
Cell culture
Confocal microscopy
Fluorescence microscopy
Protein biochemistry
Protein purification
Recombinant protein expression
X-ray crystallography
Tumour type interests
Recent publications:
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Key publications

Fiedler M, Sánchez-Barrena M, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P and Bienz M., (2008), Decoding of Methylated Histone H3 Tail by the Pygo-BCL9 Wnt Signaling Complex, Mol Cell, Vol. 30, Issue 4, Pages 507-518 Fiedler M., Mendoza-Topaz C., Rutherford T.J., Mieszczanek J., Bienz M., Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating ?-catenin, (2011), Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1937-42.
Fiedler M, Graeb M, Mieszczanek J, Rutherford TJ, Johnson CM, Bienz M (2015), An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP. Elife. 2015 Aug 27