Professor Margaret Ashcroft
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Our research focuses on understanding the molecular mechanisms regulating the cellular response to hypoxia (low oxygen). Hypoxia is a key feature associated with the pathology of many diseases, including cancer.
The main goals of the Ashcroft laboratory are to:
1) Evaluate known and novel regulators of hypoxia signalling with particular focus on the relationship between mitochondria and hypoxia inducible factors (HIFs).
2) Investigate the key cellular mechanisms regulating hypoxia responses using model systems and elucidate how these are mechanistically linked to disease.
3) Identify and develop therapeutic strategies to exploit hypoxia biology in disease.
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