Professor Margaret Ashcroft

University of Cambridge

University departments
Department of Medicine

Position: Professor
Personal home page:

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Research description

Our research focuses on understanding the molecular mechanisms regulating the cellular response to hypoxia (low oxygen). Hypoxia is a key feature associated with the pathology of many diseases, including cancer.

The main goals of the Ashcroft laboratory are to:
1) Evaluate known and novel regulators of hypoxia signalling with particular focus on the relationship between mitochondria and hypoxia inducible factors (HIFs).
2) Investigate the key cellular mechanisms regulating hypoxia responses using model systems and elucidate how these are mechanistically linked to disease.
3) Identify and develop therapeutic strategies to exploit hypoxia biology in disease.

Research Programme
Urological Malignancies
Secondary Programme
Early Detection
Methods and technologies
Bioinformatics
Cell culture
Confocal microscopy
DNA sequencing
Fluorescence microscopy
Gene expression profiling
Imaging
Immunohistochemistry
Metabolomics
Microscopy
Model organisms
PCR
Protein biochemistry
Proteomics
RNAi
Tumour type interests
Brain and central nervous system
Breast
Colorectal
Kidney
Prostate
Keywords
Hypoxia
HIF transcription factor
oxygen sensing
mitochondria
small molecule targeted agents
ma630
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Human U2OS osteosarcoma cells showing mitochondria (green, anti-ATPB), microtubules (red, anti-tubulin) and nuclei (blue, DAPI)