Professor Mark Howarth

University of Cambridge

University departments: 
Department of Pharmacology

Position: Professor
Personal home page: https://www.howarthgroup.org/
Email:   mh2186@cam.ac.uk

PubMed journal articles - click here

Professor Mark Howarth is pleased to consider applications from prospective PhD students.

Research description: 


Research Programme or Virtual Institute: 
Cancer Immunology
Secondary Programme: 
Fundamental Biology of Cancer
Methods and technologies: 
Cell culture
Fluorescence microscopy
HPLC/FPLC
Microscopy
Protein biochemistry
Protein purification
Recombinant protein expression
Tumour type interests: 
Breast
Colorectal
Oesophagus
Small intestine
Stomach
Keywords: 
antibody
receptor tyrosine kinase
CAR-T cell
neoepitope
neoantigen
immunotherapy
mh2186
Recent publications:
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Key publications: 

Simultaneous identification of viruses and viral variants with programmable DNA nanobait. Bošković F, Zhu J, Tivony R, Ohmann A, Chen K, Alawami MF, Đorđević M, Ermann N, Pereira-Dias J, Fairhead M, Howarth M, Baker S, Keyser UF. Nature Nanotechnology. 2023 Jan 16. doi: 10.1038/s41565-022-01287-x.

SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly. Vester SK, Rahikainen R, Khairil Anuar INA, Hills RA, Tan TK, Howarth M. Nature Communications 2022 Jun 28;13(1):3714.

Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid. Wicke N, Bedford MR, Howarth M. Communications Biology 2021 Aug 11;4(1):960.

NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins. Scheu AHA, Lim SYT, Metzner FJ, Mohammed S, Howarth M. Nature Communications 2021 Jan 29;12(1):717.

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice. Cohen AA, Gnanapragasam PNP, Lee YE, Hoffman PR, Ou S, Kakutani LM, Keeffe JR, Wu HJ, Howarth M, West AP, Barnes CO, Nussenzweig MC, Bjorkman PJ. Science 2021 Feb 12;371(6530):735-741.

Approaching infinite affinity through engineering of peptide-protein interaction. Keeble AH, Turkki P, Stokes S, Khairil Anuar INA, Rahikainen R, Hytönen VP*, Howarth M*. PNAS 2019 116:26523-26533.  *Corresponding authors