Professor Ming-Qing Du
Personal home page: http://www.path.cam.ac.uk/research/investigators/du/research.html
PubMed journal articles - click here
Professor Ming-Qing Du is pleased to consider applications from prospective PhD students.
Lymphomas are a group of highly heterogeneous tumors derived from B or T lymphocytes and occur at both nodal and extranodal sites. The accurate diagnosis of various lymphoma subtypes is critical in clinical management and this depends on integrated histological, immunophenotypic and molecular investigations. We have been undertaking a series of research programmes to elucidate the pathology, immunophenotype, and molecular genetics of several lymphoproliferative disorders, particularly mucosa-associated lymphoid tissue (MALT) lymphoma, splenic marginal zone lymphoma (SMZL), diffuse large B-cell lymphoma (DLBCL), enteropathy associated T cell lymphoma (EATL), Kaposi sarcoma herpes virus (KSHV) associated lymphoproliferative disorders.
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Madden L, Rosebeck S, Jin X, Appert A, Hamoudi R, Gu S, Noels H, Baens M, Du MQ, Lucas PC, McAllister-Lucas LM. (2011) Oncogenic noncanonical NF-?B activation via API2-MALT1 fusion protein mediated cleavage and stabilization of NIK. Science, 331:468-472. Hamoudi RA, Appert A, Ye H, Ruskone-Fourmestraux A, Streubel B, Chott A, Raderer M, Gong L, Wlodarska I, De Wolf-Peeters C, MacLennan KA, de Leval L, Isaacson PG, Du MQ. (2010) Differential Expression of NF-?B target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism. Leukaemia, 24:1487-97 Isaacson PG, Du MQ. (2004) MALT lymphoma: from morphology to molecule. Nature Review Cancer, 4:644-53.