Dr Helen Mott

University of Cambridge

University departments
Department of Biochemistry

Position: Assistant Director of Research
Personal home page: https://www.bioc.cam.ac.uk/research/mott

PubMed journal articles - click here

Dr Helen Mott is pleased to consider applications from prospective PhD students.

Research description

Small G proteins are molecular switches in cellular signal transduction. Many small G proteins that we are studying, such as Ras and Ral, are involved in oncogenesis and those in the Rho family, such as Cdc42 and Rac are important for invasion and metastasis. We are using a combination of structural biology and biochemical techniques to understand protein-protein interactions in the complexes formed between small G proteins and their downstream effectors. An understanding of these interactions will be crucial to the design of drugs that target these complexes. Furthermore, targetting a single effector interaction is useful for studying pathways in vivo. We are also interested in understanding how effector proteins downstream of small G proteins are modulated by their interaction with the G protein.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Secondary Programme
Not applicable

Protein NMR

Recent publications:
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Key publications

Modha R, Campbell LJ, Nietlispach D, Buhecha HR, Owen D, Mott HR. (2008) The Rac1 polybasic region is required for interaction with its effector PRK1. J Biol Chem. 283(3):1492-500. Elliot-Smith AE, Owen D, Mott HR, Lowe PN. (2008) Double mutant cycle thermodynamic analysis of the hydrophobic Cdc42-ACK protein-protein interaction. Biochemistry. 46(49):14087-99. Owen D, Campbell LJ, Littlefield K, Evetts KA, Li Z, Sacks DB, Lowe PN, Mott HR. (2008) The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem. 1692-704.