Dr Maria Alcolea

University of Cambridge

University departments
Wellcome Trust MRC Cambridge Stem Cell Institute

Position: Group leader
Personal home page: https://www.stemcells.cam.ac.uk/People/pi/alcolea

PubMed journal articles - click here

Dr Maria Alcolea is pleased to consider applications from prospective PhD students.

Research description

My recent research focuses on the study of epithelial stem and progenitor cells. Particularly, I am interested on how the normal rules governing epithelial homeostasis are lifted in order to respond to stress conditions such as wounding and cancer mutations. To answer these questions I have turned to the mouse oesophagus, which architectural simplicity renders an ideal epithelial model system for in vivo lineage tracing studies.

Research Programme
Early Detection
Keywords
Stem cells
Progenitor cells
Oesophagus
Lineage tracing
Early cancer and Mouse models.
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Recent publications:
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Key publications

-Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD, Jones PH. Differentiation imbalance in single Oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol. 2014 Jun;16(6):615- 22. -Alcolea MP, Jones PH. Tracking cells in their native habitat: lineage tracing in epithelial neoplasia. Nat Rev Cancer. 2013 Mar;13(3):161-71. Review. -Doupé DP*, Alcolea MP*, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH. (2012) A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium. Science. 2012 Aug 31;337(6098):1091-3.