Dr Maria Alcolea
Dr Maria Alcolea is pleased to consider applications from prospective PhD students.
My recent research focuses on the study of epithelial stem and progenitor cells. Particularly, I am interested on how the normal rules governing epithelial homeostasis are lifted in order to respond to stress conditions such as wounding and cancer mutations. To answer these questions I have turned to the mouse oesophagus, which architectural simplicity renders an ideal epithelial model system for in vivo lineage tracing studies.
Symplectic Elements feed provided by Research Information, University of Cambridge
-Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD, Jones PH. Differentiation imbalance in single Oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol. 2014 Jun;16(6):615- 22. -Alcolea MP, Jones PH. Tracking cells in their native habitat: lineage tracing in epithelial neoplasia. Nat Rev Cancer. 2013 Mar;13(3):161-71. Review. -Doupé DP*, Alcolea MP*, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH. (2012) A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium. Science. 2012 Aug 31;337(6098):1091-3.