Dr Michael Weekes

University of Cambridge
Department of Medicine
Cambridge Institute for Medical Research

Position: Scientific Officer
Personal home page: http://www.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/michael-weekes

PubMed journal articles - click here

Dr Michael Weekes is pleased to consider applications from prospective PhD students.

Research description

I am interested in determining how human cytomegalovirus and other intracellular pathogens evade innate immunity. We recently developed ?Quantitative Temporal Viromics?, a proteomic technique that provides a systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection. Applied to human cytomegalovirus infection, this technology provided a slew of novel data, detailing how HCMV orchestrates the expression of >8,000 cellular proteins to manipulate intrinsic, innate, and adaptive immune defences in addition to host signalling and metabolism. As well as a variety of novel innate and adaptive immune ligands, we identified viral proteins present early in infection at the cell surface, potential therapeutic targets. In addition to ongoing investigations into HCMV, I am also interested in other viral and non-viral systems, including the identification of cell surface markers of senescence in collaboration with Dr. Matthew Hoare at Cambridge CRUK.

Research Programme
Recent publications:
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Key publications

Weekes MP, Tomasec P, Huttlin EL, Fielding CA, Nusinow D, Stanton RJ, Wang EC, Aicheler R, Murrell I, Wilkinson GW, Lehner PJ and Gygi SP. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157, 1460 ? 1472 (2014). Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG and Duraisingh MT. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science 348, 711 ? 714 (2015). Weekes MP, Tan SY, Poole E, Talbot S, Antrobus R, Smith DL, Montag C, Gygi SP, Sinclair JH, Lehner PJ. Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection. Science 340, 199 ? 202 (2013).