Dr Marisa Segal

University of Cambridge

University departments
Department of Genetics

Position: Senior Lecturer
Personal home page: http://www.gen.cam.ac.uk/research/segal.html

PubMed journal articles - click here

Dr Marisa Segal is pleased to consider applications from prospective PhD students.

Research description

Spindle morphogenesis is regulated by cyclin-dependent kinases (CDKs) and monitored by checkpoints to enforce accurate chromosomal segregation and spatial coupling between the axis of the mitotic spindle and the division plane. These controls safeguard genetic integrity over cell divisions. Furthermore, regulated orientation of the mitotic spindle during development can produce asymmetric divisions with progeny cells differing in their developmental fate. The budding yeast S. cerevisiae is one of the best models for exploring cell cycle controls during an asymmetric division that gives rise to mother and daughter cells. In S. cerevisiae, the mitotic spindle becomes positioned near the bud neck and orients along the mother-bud axis prior to anaphase. This alignment ensures that the daughter cell receives one set of chromosomes during spindle elongation across the bud neck. Spindle assembly and orientation are controlled by the spindle pole bodies (SPBs), the functional counterparts of the centrosomes of animal cells. As part of our goal to dissect cell cycle control of spindle morphogenesis in S. cerevisiae we have focused on the events that determine SPB asymmetry or spindle polarity, i.e. the mechanisms directing one pole towards the daughter while retaining the second pole in the mother cell, bringing about orientation of the spindle. This entails two levels of control, currently under study in our lab.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Recent publications:
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Key publications

Juanes MA, Twyman H, Tunnacliffe E, Guo Z, Ten Hoopen R, Segal M. (2013) Spindle pole body history intrinsically links pole identity with asymmetric fate in budding yeast. Curr Biol. Jul 22;23(14):1310-9. Ten Hoopen R, Cepeda-García C, Fernández-Arruti R, Juanes MA, Delgehyr N, Segal M. (2012) Mechanism for astral microtubule capture by cortical Bud6p priming spindle polarity in S. cerevisiae. Curr Biol. Jun 19;22(12):1075-83. Juanes MA, ten Hoopen R, Segal M. Ase1p phosphorylation by cyclin-dependent kinase promotes correct spindle assembly in S. cerevisiae. (2011) Cell Cycle Jun 15;10(12):1988-97.