Professor Nicholas Coleman
Professor Nicholas Coleman is pleased to consider applications from prospective PhD students.
Our group aims to translate basic scientific advances into improvements in the clinical management of neoplastic disease. We work in two main areas: 1. Development and evaluation of novel markers for improved cancer screening Early detection of cancer by screening will remain one of the most effective (and cost-effective) methods for improving cancer survival in the short- and medium-term. We aim to drive testing for minichromosome maintenance (MCM) proteins into clinical practice, with emphasis on applications in cervical, lung and colorectal cancer screening. 2. Mechanisms of cervical neoplastic progression We are addressing the contribution to cervical neoplastic progression of variables relating to high risk human papillomavirus (HPV) infection, using clinical samples and a unique model of cervical neoplastic progression, the W12 cell line.
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1. Ng G, Winder D, Muralidhar B, Gooding E, Roberts I, Pett M, Mukherjee G, Huang J, Coleman N (2007) Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome. Journal of Pathology 212:325-34. 2. Pett MR, Herdman MT, Palmer RD, Yeo GS, Shivji MK, Stanley MA, Coleman N (2006) Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. Proceedings of the National Academy of Sciences USA 103:3822-27 3. Herdman MT, Pett MR, Roberts I, Alazawi WO, Teschendorff AE, Zhang XY, Stanley MA, Coleman N. (2006) Interferon-beta treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants. Carcinogenesis 27:2341-53