Dr Paul Lyons

University of Cambridge
Department of Medicine
Cambridge Institute for Medical Research

Position: Senior Research Associate
Personal home page: http://www.med.cam.ac.uk/nephrology/research/chictriad.html

PubMed journal articles - click here

Dr Paul Lyons is pleased to consider applications from prospective PhD students.

Research description

My long standing research interest has involved understanding the genetic basis of susceptibility to autoimmune disease. More recently I have been involved in the establishment of the Cambridge Hinxton Centre for Translational Research in Autoimmune Disease. This is a collaboration between clinicians, basic scientists and bioinformaticians that aims to apply expression profiling to the clinical management of autoimmune diseases such as systemic lupus erythematosus and small vessel vasculitis. This approach will enable the development of novel biomarkers that can be used to stratify patients at presentation, select appropriate treatment protocols, monitor response and predict relapse. In addition, it may also provide insight into the molecular pathogenesis of disease.

Research Programme
Onco-Innovation
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Recent publications:
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Key publications

Petalidis L, Bhattacharrya S, Morris GA, Collins VP, Freeman TC and Lyons PA (2003) Global Amplification of mRNA by Template-Switching PCR: Linearity and Application to Microarray Analysis. Nucleic Acids Research 31: e142 Newland SA, Macaulay IC, Floto RA, de Vet EC, Ouwehand WH, Watkins NA, Lyons PA * and Campbell RD * (2007) The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. Blood 109:4806-4809 Lyons PA, Koukoulaki M, Hatton A, Doggett K, Woffendin HB, Chaudhry AN and Smith KGC (2007) Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification. BMC Genomics 8:64