Professor Paul Pharoah
Position: Professor
Personal home page:
http://ccge.medschl.cam.ac.uk/dr-paul-pharoah/
Email:
pp10001@medschl.cam.ac.uk
PubMed journal articles - click here
Professor Paul Pharoah is pleased to consider applications from prospective PhD students.
I am interested in the architecture of genetic susceptibility to common cancers (primarily breast, ovarian and colorectal). I am also interested in understanding how germline genetic variation influences disease heterogeneity and heterogeneity in the clinical outcomes of cancer.
Symplectic Elements feed provided by Research Information, University of Cambridge
1. Pharoah PD, H Song, E Dicks, MP Intermaggio, P Harrington, C Baynes, K Alsop, G Australian Ovarian Cancer Study, N Bogdanova, MS Cicek, JM Cunningham, BL Fridley, A Gentry-Maharaj, P Hillemanns, S Lele, J Lester, V McGuire, KB Moysich, S Poblete, W Sieh, L Sucheston-Campbell, M Widschwendter, C Ovarian Cancer Association, AS Whittemore, T Dork, U Menon, K Odunsi, EL Goode, BY Karlan, DD Bowtell, SA Gayther, SJ Ramus (2016) Mar PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations. J. Natl. Cancer Inst. 108. 26823519
2. Kar SP, J Beesley, A Amin Al Olama, K Michailidou, J Tyrer, Z Kote-Jarai, K Lawrenson, S Lindstrom, SJ Ramus, DJ Thompson, A Investigators, AS Kibel, A Dansonka-Mieszkowska, A Michael, AK Dieffenbach, A Gentry-Maharaj, AS Whittemore, A Wolk, A Monteiro, A Peixoto, A Kierzek, A Cox, A Rudolph, A Gonzalez-Neira, AH Wu, A Lindblom, A Swerdlow, AS Group, S Australian Cancer, A BioResource, A Ziogas, AB Ekici, B Burwinkel, BY Karlan, BG Nordestgaard, C Blomqvist, C Phelan, C McLean, CL Pearce, C Vachon, C Cybulski, C Slavov, C Stegmaier, C Maier, CB Ambrosone, CK Hogdall, CC Teerlink, D Kang, DC Tessier, DJ Schaid, DO Stram, DW Cramer, DE Neal, D Eccles, D Flesch-Janys, DR Edwards, D Wokozorczyk, DA Levine, D Yannoukakos, EJ Sawyer, EV Bandera, EM Poole, EL Goode, E Khusnutdinova, E Hogdall, F Song, F Bruinsma, F Heitz, F Modugno, FC Hamdy, F Wiklund, GG Giles, H Olsson, H Wildiers, HU Ulmer, H Pandha, HA Risch, H Darabi, HB Salvesen, H Nevanlinna, H Gronberg, H Brenner, H Brauch, H Anton-Culver, H Song, HY Lim, I McNeish, I Campbell, I Vergote, J Gronwald, J Lubinski, JL Stanford, J Benitez, JA Doherty, JB Permuth, J Chang-Claude, JL Donovan, J Dennis, JM Schildkraut, J Schleutker, JL Hopper, J Kupryjanczyk, JY Park, J Figueroa, JA Clements, JA Knight, J Peto, JM Cunningham, J Pow-Sang, J Batra, K Czene, KH Lu, K Herkommer, KT Khaw, I kConFab, K Matsuo, K Muir, K Offitt, K Chen, KB Moysich, K Aittomaki, K Odunsi, LA Kiemeney, LF Massuger, LM Fitzgerald, LS Cook, L Cannon-Albright, MJ Hooning, MC Pike, MK Bolla, M Luedeke, MR Teixeira, MT Goodman, MK Schmidt, M Riggan, M Aly, MA Rossing, MW Beckmann, M Moisse, M Sanderson, MC Southey, M Jones, M Lush, MA Hildebrandt, MF Hou, MJ Schoemaker, M Garcia-Closas, N Bogdanova, N Rahman, N Investigators, ND Le, N Orr, N Wentzensen, N Pashayan, P Peterlongo, P Guenel, P Brennan, P Paulo, PM Webb, P Broberg, PA Fasching, P Devilee, Q Wang, Q Cai, Q Li, R Kaneva, R Butzow, RK Kopperud, RK Schmutzler, RA Stephenson, RJ MacInnis, RN Hoover, R Winqvist, R Ness, RL Milne, RC Travis, S Benlloch, SH Olson, SK McDonnell, SS Tworoger, S Maia, S Berndt, SC Lee, SH Teo, SN Thibodeau, SE Bojesen, SM Gapstur, SK Kjaer, T Pejovic, TL Tammela, G Network, P consortium, T Dork, T Bruning, T Wahlfors, TJ Key, TL Edwards, U Menon, U Hamann, V Mitev, VM Kosma, VW Setiawan, V Kristensen, V Arndt, W Vogel, W Zheng, W Sieh, WJ Blot, W Kluzniak, XO Shu, YT Gao, F Schumacher, ML Freedman, A Berchuck, AM Dunning, J Simard, CA Haiman, A Spurdle, TA Sellers, DJ Hunter, BE Henderson, P Kraft, SJ Chanock, FJ Couch, P Hall, SA Gayther, DF Easton, G Chenevix-Trench, R Eeles, PD Pharoah, D Lambrechts (2016) Jul 17 Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov. 27432226
3. Ramus SJ, H Song, E Dicks, JP Tyrer, AN Rosenthal, MP Intermaggio, L Fraser, A Gentry-Maharaj, J Hayward, S Philpott, C Anderson, CK Edlund, D Conti, P Harrington, D Barrowdale, DD Bowtell, K Alsop, G Mitchell, AS Group, MS Cicek, JM Cunningham, BL Fridley, J Alsop, M Jimenez-Linan, S Poblete, S Lele, L Sucheston-Campbell, KB Moysich, W Sieh, V McGuire, J Lester, N Bogdanova, M Durst, P Hillemanns, C Ovarian Cancer Association, K Odunsi, AS Whittemore, BY Karlan, T Dork, EL Goode, U Menon, IJ Jacobs, AC Antoniou, PD Pharoah, SA Gayther (2015) Nov Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. J. Natl. Cancer Inst. 107. 26315354
4. Kuchenbaecker KB, SJ Ramus, J Tyrer, A Lee, HC Shen, J Beesley, K Lawrenson, L McGuffog, S Healey, JM Lee, TJ Spindler, YG Lin, T Pejovic, Y Bean, Q Li, S Coetzee, D Hazelett, A Miron, M Southey, MB Terry, DE Goldgar, SS Buys, R Janavicius, CM Dorfling, EJ van Rensburg, SL Neuhausen, YC Ding, TV Hansen, L Jonson, AM Gerdes, B Ejlertsen, D Barrowdale, J Dennis, J Benitez, A Osorio, MJ Garcia, I Komenaka, JN Weitzel, P Ganschow, P Peterlongo, L Bernard, A Viel, B Bonanni, B Peissel, S Manoukian, P Radice, L Papi, L Ottini, F Fostira, I Konstantopoulou, J Garber, D Frost, J Perkins, R Platte, S Ellis, Embrace, AK Godwin, RK Schmutzler, A Meindl, C Engel, C Sutter, OM Sinilnikova, GS Collaborators, F Damiola, S Mazoyer, D Stoppa-Lyonnet, K Claes, K De Leeneer, J Kirk, GC Rodriguez, M Piedmonte, DM O'Malley, M de la Hoya, T Caldes, K Aittomaki, H Nevanlinna, JM Collee, MA Rookus, JC Oosterwijk, R Breast Cancer Family, L Tihomirova, N Tung, U Hamann, C Isaccs, M Tischkowitz, EN Imyanitov, MA Caligo, IG Campbell, FB Hogervorst, Hebon, E Olah, O Diez, I Blanco, J Brunet, C Lazaro, MA Pujana, A Jakubowska, J Gronwald, J Lubinski, G Sukiennicki, RB Barkardottir, M Plante, J Simard, P Soucy, M Montagna, S Tognazzo, MR Teixeira, KC Investigators, VS Pankratz, X Wang, N Lindor, CI Szabo, N Kauff, J Vijai, CA Aghajanian, G Pfeiler, A Berger, CF Singer, MK Tea, CM Phelan, MH Greene, PL Mai, G Rennert, AM Mulligan, S Tchatchou, IL Andrulis, G Glendon, AE Toland, UB Jensen, TA Kruse, M Thomassen, A Bojesen, J Zidan, E Friedman, Y Laitman, M Soller, A Liljegren, B Arver, Z Einbeigi, M Stenmark-Askmalm, OI Olopade, RL Nussbaum, TR Rebbeck, KL Nathanson, SM Domchek, KH Lu, BY Karlan, C Walsh, J Lester, S Australian Cancer, G Australian Ovarian Cancer Study, A Hein, AB Ekici, MW Beckmann, PA Fasching, D Lambrechts, E Van Nieuwenhuysen, I Vergote, S Lambrechts, E Dicks, JA Doherty, KG Wicklund, MA Rossing, A Rudolph, J Chang-Claude, S Wang-Gohrke, U Eilber, KB Moysich, K Odunsi, L Sucheston, S Lele, LR Wilkens, MT Goodman, PJ Thompson, YB Shvetsov, IB Runnebaum, M Durst, P Hillemanns, T Dork, N Antonenkova, N Bogdanova, A Leminen, LM Pelttari, R Butzow, F Modugno, JL Kelley, RP Edwards, RB Ness, A du Bois, F Heitz, I Schwaab, P Harter, K Matsuo, S Hosono, S Orsulic, A Jensen, SK Kjaer, E Hogdall, HN Hasmad, MA Azmi, SH Teo, YL Woo, BL Fridley, EL Goode, JM Cunningham, RA Vierkant, F Bruinsma, GG Giles, D Liang, MA Hildebrandt, X Wu, DA Levine, M Bisogna, A Berchuck, ES Iversen, JM Schildkraut, P Concannon, RP Weber, DW Cramer, KL Terry, EM Poole, SS Tworoger, EV Bandera, I Orlow, SH Olson, C Krakstad, HB Salvesen, IL Tangen, L Bjorge, AM van Altena, KK Aben, LA Kiemeney, LF Massuger, M Kellar, A Brooks-Wilson, LE Kelemen, LS Cook, ND Le, C Cybulski, H Yang, J Lissowska, LA Brinton, N Wentzensen, C Hogdall, L Lundvall, L Nedergaard, H Baker, H Song, D Eccles, I McNeish, J Paul, K Carty, N Siddiqui, R Glasspool, AS Whittemore, JH Rothstein, V McGuire, W Sieh, BT Ji, W Zheng, XO Shu, YT Gao, B Rosen, HA Risch, JR McLaughlin, SA Narod, AN Monteiro, A Chen, HY Lin, J Permuth-Wey, TA Sellers, YY Tsai, Z Chen, A Ziogas, H Anton-Culver, A Gentry-Maharaj, U Menon, P Harrington, AW Lee, AH Wu, CL Pearce, G Coetzee, MC Pike, A Dansonka-Mieszkowska, A Timorek, IK Rzepecka, J Kupryjanczyk, M Freedman, H Noushmehr, DF Easton, K Offit, FJ Couch, S Gayther, PP Pharoah, AC Antoniou, G Chenevix-Trench, B Consortium of Investigators of Modifiers of, Brca (2015) Feb Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat. Genet. 47, 164-71. 25581431
5. Guo Q, MK Schmidt, P Kraft, S Canisius, C Chen, S Khan, J Tyrer, MK Bolla, Q Wang, J Dennis, K Michailidou, M Lush, S Kar, J Beesley, AM Dunning, M Shah, K Czene, H Darabi, M Eriksson, D Lambrechts, C Weltens, K Leunen, SE Bojesen, BG Nordestgaard, SF Nielsen, H Flyger, J Chang-Claude, A Rudolph, P Seibold, D Flesch-Janys, C Blomqvist, K Aittomaki, R Fagerholm, TA Muranen, FJ Couch, JE Olson, C Vachon, IL Andrulis, JA Knight, G Glendon, AM Mulligan, A Broeks, FB Hogervorst, CA Haiman, BE Henderson, F Schumacher, L Le Marchand, JL Hopper, H Tsimiklis, C Apicella, MC Southey, A Cox, SS Cross, MW Reed, GG Giles, RL Milne, C McLean, R Winqvist, K Pylkas, A Jukkola-Vuorinen, M Grip, MJ Hooning, A Hollestelle, JW Martens, AM van den Ouweland, F Marme, A Schneeweiss, R Yang, B Burwinkel, J Figueroa, SJ Chanock, J Lissowska, EJ Sawyer, I Tomlinson, MJ Kerin, N Miller, H Brenner, AK Dieffenbach, V Arndt, B Holleczek, A Mannermaa, V Kataja, VM Kosma, JM Hartikainen, J Li, JS Brand, K Humphreys, P Devilee, RA Tollenaar, C Seynaeve, P Radice, P Peterlongo, B Bonanni, P Mariani, PA Fasching, MW Beckmann, A Hein, AB Ekici, G Chenevix-Trench, R Balleine, I kConFab, KA Phillips, J Benitez, MP Zamora, JI Arias Perez, P Menendez, A Jakubowska, J Lubinski, K Jaworska-Bieniek, K Durda, U Hamann, M Kabisch, HU Ulmer, T Rudiger, S Margolin, V Kristensen, S Nord, DG Evans, JE Abraham, HM Earl, L Hiller, JA Dunn, S Bowden, C Berg, D Campa, WR Diver, SM Gapstur, MM Gaudet, SE Hankinson, RN Hoover, A Husing, R Kaaks, MJ Machiela, W Willett, M Barrdahl, F Canzian, SF Chin, C Caldas, DJ Hunter, S Lindstrom, M Garcia-Closas, P Hall, DF Easton, DM Eccles, N Rahman, H Nevanlinna, PD Pharoah (2015) May Identification of novel genetic markers of breast cancer survival. J. Natl. Cancer Inst. 107. 25890600
6. Easton DF, PD Pharoah, AC Antoniou, M Tischkowitz, SV Tavtigian, KL Nathanson, P Devilee, A Meindl, FJ Couch, M Southey, DE Goldgar, DG Evans, G Chenevix-Trench, N Rahman, M Robson, SM Domchek, WD Foulkes (2015) Jun 4 Gene-panel sequencing and the prediction of breast-cancer risk. N. Engl. J. Med. 372, 2243-57. 26014596
7. Song H, MS Cicek, E Dicks, P Harrington, SJ Ramus, JM Cunningham, BL Fridley, JP Tyrer, J Alsop, M Jimenez-Linan, SA Gayther, EL Goode, PD Pharoah (2014) Sep 1 The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population. Hum. Mol. Genet. 23, 4703-9. 24728189
8. Pharoah PD, YY Tsai, SJ Ramus, CM Phelan, EL Goode, K Lawrenson, M Buckley, BL Fridley, JP Tyrer, H Shen, R Weber, R Karevan, MC Larson, H Song, DC Tessier, F Bacot, D Vincent, JM Cunningham, J Dennis, E Dicks, KK Aben, H Anton-Culver, N Antonenkova, SM Armasu, L Baglietto, EV Bandera, MW Beckmann, MJ Birrer, G Bloom, N Bogdanova, JD Brenton, LA Brinton, A Brooks-Wilson, R Brown, R Butzow, I Campbell, ME Carney, RS Carvalho, J Chang-Claude, YA Chen, Z Chen, WH Chow, MS Cicek, G Coetzee, LS Cook, DW Cramer, C Cybulski, A Dansonka-Mieszkowska, E Despierre, JA Doherty, T Dork, A du Bois, M Durst, D Eccles, R Edwards, AB Ekici, PA Fasching, D Fenstermacher, J Flanagan, YT Gao, M Garcia-Closas, A Gentry-Maharaj, G Giles, A Gjyshi, M Gore, J Gronwald, Q Guo, MK Halle, P Harter, A Hein, F Heitz, P Hillemanns, M Hoatlin, E Hogdall, CK Hogdall, S Hosono, A Jakubowska, A Jensen, KR Kalli, BY Karlan, LE Kelemen, LA Kiemeney, SK Kjaer, GE Konecny, C Krakstad, J Kupryjanczyk, D Lambrechts, S Lambrechts, ND Le, N Lee, J Lee, A Leminen, BK Lim, J Lissowska, J Lubinski, L Lundvall, G Lurie, LF Massuger, K Matsuo, V McGuire, JR McLaughlin, U Menon, F Modugno, KB Moysich, T Nakanishi, SA Narod, RB Ness, H Nevanlinna, S Nickels, H Noushmehr, K Odunsi, S Olson, I Orlow, J Paul, T Pejovic, LM Pelttari, J Permuth-Wey, MC Pike, EM Poole, X Qu, HA Risch, L Rodriguez-Rodriguez, MA Rossing, A Rudolph, I Runnebaum, IK Rzepecka, HB Salvesen, I Schwaab, G Severi, H Shen, V Shridhar, XO Shu, W Sieh, MC Southey, P Spellman, K Tajima, SH Teo, KL Terry, PJ Thompson, A Timorek, SS Tworoger, AM van Altena, D van den Berg, I Vergote, RA Vierkant, AF Vitonis, S Wang-Gohrke, N Wentzensen, AS Whittemore, E Wik, B Winterhoff, YL Woo, AH Wu, HP Yang, W Zheng, A Ziogas, F Zulkifli, MT Goodman, P Hall, DF Easton, CL Pearce, A Berchuck, G Chenevix-Trench, E Iversen, AN Monteiro, SA Gayther, JM Schildkraut, TA Sellers (2013) Apr GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat. Genet. 45, 362-70. 23535730
9. Bolton KL, G Chenevix-Trench, C Goh, S Sadetzki, SJ Ramus, BY Karlan, D Lambrechts, E Despierre, D Barrowdale, L McGuffog, S Healey, DF Easton, O Sinilnikova, J Benitez, MJ Garcia, S Neuhausen, MH Gail, P Hartge, S Peock, D Frost, DG Evans, R Eeles, AK Godwin, MB Daly, A Kwong, ES Ma, C Lazaro, I Blanco, M Montagna, E D'Andrea, MO Nicoletto, SE Johnatty, SK Kjaer, A Jensen, E Hogdall, EL Goode, BL Fridley, JT Loud, MH Greene, PL Mai, A Chetrit, F Lubin, G Hirsh-Yechezkel, G Glendon, IL Andrulis, AE Toland, L Senter, ME Gore, C Gourley, CO Michie, H Song, J Tyrer, AS Whittemore, V McGuire, W Sieh, U Kristoffersson, H Olsson, A Borg, DA Levine, L Steele, MS Beattie, S Chan, RL Nussbaum, KB Moysich, J Gross, I Cass, C Walsh, AJ Li, R Leuchter, O Gordon, M Garcia-Closas, SA Gayther, SJ Chanock, AC Antoniou, PD Pharoah (2012) Jan 25 Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. J.A.M.A. 307, 382-90. 22274685
10. Pharoah PD, AC Antoniou, DF Easton, BA Ponder (2008) Jun 26 Polygenes, risk prediction, and targeted prevention of breast cancer. N. Engl. J. Med. 358, 2796-803. 18579814
11. Pharoah PD, A Antoniou, M Bobrow, RL Zimmern, DF Easton, BA Ponder (2002) May Polygenic susceptibility to breast cancer and implications for prevention. Nat. Genet. 31, 33-6. 11984562