Dr Pier Paolo D'Avino

University of Cambridge

University departments
Department of Pathology

Position: Lecturer
Personal home page: http://www.path.cam.ac.uk/research/investigators/davino/

PubMed journal articles - click here

Dr Pier Paolo D'Avino is pleased to consider applications from prospective PhD students.

Research description

Defects in cell division often cause abnormal distribution of the genetic material between the two daughter cells. These abnormalities generate genetic instability, which is widely considered as a major factor in the onset and development of human cancer. Therefore, understanding the mechanisms that control the activity of cell cycle regulatory proteins may lead to the identification of therapeutic targets for the treatment of tumour pathologies. My current research focuses on the study of the mechanisms and signalling pathways that control mitosis and cytokinesis using Drosophila and vertebrate tissue culture cells as model systems.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Methods and technologies
Cell culture
Confocal microscopy
Fluorescence microscopy
Protein biochemistry
Tumour type interests
Recent publications:
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Key publications

D?Avino, P.P. and Glover D.M. (2009) Cytokinesis: mind the GAP. Nature Cell Biology, 11:112-114. D?Avino, P.P. (2009) How to scaffold the contractile ring for a safe cytokinesis ? lessons from Anillin related proteins. Journal of Cell Science, 122:1071-1079. Montambault, E., Zhang, W., Przewloka, M.R, Archambault, V., Sevin, E.W., Laue, E.D., Glover D.M. and D?Avino, P.P. (2010) Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes. Journal of Cell Biology, 191:1351-1365. Capalbo, L., D?Avino, P.P., Archambault, V., and Glover D.M. (2011) Rab5 GTPase controls chromosome alignment through Lamin disassembly of and relocation of the NuMA like protein Mud to the poles during mitosis. Proceedings of the National Academy of Sciences USA, 108:17343-8. Bassi, I.Z., Verbrugghe, K.J., Capalbo, L., Gregory, S., Montembault, E., Glover D.M. and D?Avino P.P. (2011) Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. Journal of Cell Biology, 195(4):595-603. Capalbo, L., Montembault, E., Takeda, T., Bassi, Z.I., Glover D.M. and D?Avino PP. (2012). The Chromosomal Passenger Complex controls the function of ESCRT-III Snf7 proteins during cytokinesis. Open Biology, 2, 120070 (doi: 10.1098/rsob.120070). Bassi I.Z., Audusseau, M., Riparbelli, M.G., Callaini, G. and D?Avino P.P. (2013) Citron kinase controls a molecular network required for midbody formation in cytokinesis. Proceedings of the National Academy of Sciences USA, 110(24):9782-9787.

An organelle required for cytokinesis, dubbed midbody, was purified from HeLa cells and stained to detect microtubules (red) and Citron kinase (green)