Dr Rahul Samant

Babraham Institute

Position: Group Leader
Personal home page: https://www.babraham.ac.uk/our-research/signalling/rahul-samant
Email:   rahul.samant@babraham.ac.uk

PubMed journal articles - click here

Dr Rahul Samant is pleased to consider applications from prospective PhD students.

Research description

My lab at the Babraham Institute is probing how different protein clearance pathways--with a focus on the ubiquitin-proteasome system and autophagy--are integrated to maintain proteome balance ('proteostasis') in healthy cells, and how these disintegrate during ageing and ageing-related diseases, including cancers and neurodegeneration.

We use a multi-disciplinary approach with an emphasis on mass spectrometry-based proteomic methods together with cutting-edge cell and molecular biology tools for probing ubiquitin-mediated protein clearance pathways. By performing studies in a range of model systems—from single-celled budding yeast, to humans—we hope to unravel underlying rules governing proteostasis conserved throughout evolution, development, and ageing.

Our current focus is on the use of drugs targeting the molecular chaperone HSP90—a key regulator of proteostasis—to investigate the plasticity of protein clearance pathways in young, aged, and diseased cells.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Methods and technologies
Cell culture
Fluorescence microscopy
Model organisms
Tumour type interests
Recent publications:
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Key publications

Samant RS, Livingston CM, Sontag EM, Frydman J “Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control.” Nature 2018; 563:407-411. https://dx.doi.org/10.1038/s41586-018-0678-x

Sontag EM*, Samant RS* (equal contribution), Frydman J “Mechanisms and functions of spatial protein quality control.” Annu Rev Biochem 2017; 86:33.1-33.26. https://dx.doi.org/10.1146/annurev-biochem-060815-014616

Samant RS, Clarke PA, Workman P “E3 ubiquitin ligase CUL5 modulates multiple molecular and cellular responses to HSP90 inhibition in human colon cancer cells.” Proc Natl Acad Sci USA 2014; 111:6834-6839. https://dx.doi.org/10.1073/pnas.1322412111