Dr Richard Baird

Cambridge University Hospitals NHS Foundation Trust

University departments
Department of Oncology
University institutes
CRUK Cambridge Institute
NHS or other affiliations
Honorary Consultant Medical Oncologist - Addenbrooke's Hospital

Position: Academic Consultant in Experimental Cancer Therapeutics
Personal home page: http://www.mendeley.com/profiles/richard-baird/
Email:   richard.baird@medschl.cam.ac.uk

PubMed journal articles - click here

Dr Richard Baird is pleased to consider applications from prospective PhD students.

Research description

Early phase clinical trials, including expertise in:
- first-in-human studies & drug combination trials
- new small molecule & antibody therapeutics
- development of pharmacodynamic and predictive biomarkers
- novel clinical trial designs including Bayesian / adaptive approaches

Focus on breast cancer therapeutics.

Investigator-initiated clinical trials funded by: 
- Cancer Research UK 
- Brain Tumour Charity 
- EU Framework 7 (RATHER consortium, EUROCAN platform)
- AntiCancer Fund
- AstraZeneca 
- Boehringer-Ingelheim
- Genentech
- Medimmune

Research Programme or Virtual Institute
Precision Breast Cancer Institute
Strategic Resources
Cambridge Experimental Cancer Medicine Centre (ECMC)
Recent publications:
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Key publications

Baird RD et al. First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors. Journal of Clinical Oncology (in press)

Ros S et al. Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER + Breast Cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2020.08.016 (2020)

Turner N, Kingston B, Kilburn L, Kernaghan, Wardley A, Macpherson I, Baird RD et al. Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial. Lancet Oncology. https://doi.org/10.1016/S1470-2045(20)30444-7 (2020)

Baird RD, van Rossum AGJ, Oliveira M, ... Cortès J, Caldas C, Linn SC. POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-19-0508. (2019)

Ahmad SS ... Sharma RA. Clinical Development of Novel Drug-Radiotherapy Combinations. Clinical Cancer Research https://doi.org/10.1158/1078-0432.CCR-18-2466 (2019)

Paoletti C ... Baird RD, Hayes DF. Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers: Correlative Results from AZD9496 Oral SERD Phase I Trial. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-18-1569 (2018)

Mouliere F ... Rosenfeld N. Enhanced detection of circulating tumor DNA by fragment size analysis. Science Translational Medicine 2018 Nov 7;10(466). https://doi.org/10.1126/scitranslmed.aat4921 (2018)

Hamilton EP, Patel MR, Armstrong AC, Baird RD, ... Im SA. A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER+/HER2- Advanced Breast Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-17-3102 (2018)

Wan, J., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J., Caldas, C., Pacey, S., Baird, R.D.*, Rosenfeld, N*. Liquid biopsies come of age: towards implementation of circulating tumour DNA. Nature Reviews Cancer. https://doi.org/10.1038/nrc.2017.7 (2017)

Selby P, Lawler M, Baird R, Banks I, Johnston P, Nurse P. The potential consequences for cancer care and cancer research of Brexit. Ecancermedicalscience. Feb 24;11:ed63. https://doi.org/10.3332/ecancer.2017.ed63 (2017)

Bruna A ... Caldas C. A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds. Cell. https://doi.org/10.1016/j.cell.2016.08.041 (2016)

Sharma RA et al. Clinical development of new drug–radiotherapy combinations. Nature Reviews Clinical Oncology. https://doi.org/10.1038/nrclinonc.2016.79 (2016).

Ang JE, Pandher R, Ang JC, Asad Y, Henley AT, Valenti M, Box G, de Haven Brandon A, Baird RD, Friedman L, et al. Plasma metabolomic changes following PI3K inhibition as pharmacodynamic biomarkers: preclinical discovery to Phase I trial evaluation. Mol. Cancer Ther. 15, 1412–1424 (2016).

Baird RD, et al. An Association of Cancer Physicians’ strategy for improving services and outcomes for cancer patients. Ecancermedicalscience 10, 1–58 (2016).

Baird RD & Carroll JS. Understanding Oestrogen Receptor Function in Breast Cancer and its Interaction with the Progesterone Receptor. New Preclinical Findings and their Clinical Implications. Clin. Oncol. 28, 1–3 (2016).

Wason JMS, Abraham JE, Baird RD, et al. A Bayesian adaptive design for biomarker trials with linked treatments. Br. J. Cancer 113, 699–705 (2015).

Spicer JF, Baird RD, et al. Phase 1 dose-escalation study of S-222611, an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, in patients with solid tumours. Eur. J. Cancer 51, 137–145 (2015).

Tolcher AW, Khan K, Ong M, Banerji U, Papadimitrakopoulou V, Gandara DR, Patnaik A, Baird RD, et al. Antitumor Activity in RAS-Driven Tumors by Blocking AKT and MEK. Clin. Cancer Res. 21, 739–748 (2014).

Sarker D, Ang J, Baird RD, et al. First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors. Clin. Cancer Res. 21, 77–86 (2014).

Baird RD & Caldas C. Genetic heterogeneity in breast cancer: the road to personalized medicine? BMC Medicine 11 (1), 151 (2013).

Sandhu, S.K., Schelman, W.R., Wilding, G., Moreno, V., Baird RD, et al. The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. Lancet Oncology 2045 (13), 882-892 (2013).

Venugopal B*, Baird RD*, et al. A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors. Clinical Cancer Research 19 (15), 4262-4272 (2013).

Olmos D*, Baird RD*, Yap T, Papadatos-Pastos D, Sandhu S, Massard C, De Bono JS. Addition of baseline circulating tumour cell count improves the Royal Marsden Hospital prognostic score to select patients for oncology phase 1 trials. Clinical Cancer Research 17(15):5188-96 (2011).

Baird RD, Planting A, Reid AHM, Kitzen J, de las Heras B, Eskens F, de Bono JS, Workman P, Verweij J (2009). A phase 1 dose escalation, pharmacokinetic and pharmacogenomic study of ES-285, a novel marine cytotoxic agent, administered as an intravenous infusion over 24h every 21 days in patients with advanced solid tumours. Molecular Cancer Therapeutics 8(6): 1430-1437