Dr Roisin Owens

University of Cambridge

University departments
Department of Chemical Engineering and Biotechnology

Position: Lecturer
Personal home page: https://www.ceb.cam.ac.uk/research/groups/best
Email:   Public email address:  rmo37@cam.ac.uk

PubMed journal articles - click here

Dr Roisin Owens is pleased to consider applications from prospective PhD students.

Research description

Our group works on integrating biological models with electronic devices to generate systems that can be predictive of real biological systems, for drug discovery and therapeutics. We combine expertise in a wide range of disciplines including biochemistry, microbiology and cell biology on the bio side, to materials science, electronics and chemistry on the physical sciences and engineering side. We have two main activities, development of 3D organ on chip models of human tissues and organs and generation of native, complete membranes from human cells. In both cases we integrate with novel conducting polymer devices that can read out the biological function of the tissues and membranes and can thus be used to predict drug/therapeutic agent effect. We are currently working with the MRC Cancer Unit in Camridge to use our devices for impedance monitoring of tissue biopsies.

Research Programme
Early Detection
Methods and technologies
Biosensor
Cell culture
Confocal microscopy
Imaging
Model organisms
Other
Tumour type interests
Colorectal
Lung
Oesophagus
Small intestine
Stomach

Key publications

S. Inal, A. Hama, M. Ferro, C. Pitsalidis, J. Oziat, D. Iandolo, A-M Pappa, M. Hadida, M. Huerta, D. Marchat, P. Mailley, R. M. Owens. Conducting Polymer Scaffolds for Monitoring 3D Cell Culture. Advanced Biosystems early online view http://dx.doi.org/10.1002/adbi.201700052. (2017)
V. Curto, A. Hama, B. Marchiori, A-M. Pappa, M. Braendlein, and R. M. Owens. A multi-parametric organic transistor platform with integrated microfluidics for in-line in vitro cell monitoring. Nature Microsystems & Nanoengineering 3: 17028 (2017) doi:10.1038/micronano.2017.28
J. Rivnay, M. Ramuz, P. Leleux, A. Hama, M. Huerta and R.M. Owens, "Organic electrochemical transistors for cell-based impedance sensing". Appl Phys Lett 106 (4), 043301 (2015)
M. Ramuz, A. Hama, M. Huerta, J. Rivnay, P. Leleux, R.M. Owens. “Combined optical/electronic monitoring of epithelial cells in vitro”. Adv. Mat. 26 (41) 7083-7090 (2014)
S. Tria, M. Ramuz, M. Huerta, P. Leleux, J. Rivnay, L. Jimison, A. Hama, G. G. Malliaras, R.M. Owens. “Dynamic detection of Salmonella typhimurium infection of polarised epithelia using organic transistors”. AHM 3 (7) 1053-60. (2014)
X. Strakosas, M. Sessolo, A. Hama, J. Rivnay, E. Stavrinidou, G.G. Malliaras, and R.M. Owens. “facile biofunctionalisation route for solution processable conducting polymer devices”. J. Mater. Chem. B. 2, 2537-2545 (2014)
J. Rivnay, R.M. Owens, and G.G. Malliaras. “The Rise of Organic Bioelectronics”. Chemistry of Materials, 26 (1); 679-685 (2014).

Conducting polymer devices integrated into fluidic organ on chip format (left). The device contains an electroactive scaffold (top right) which can host and monitor cells grown inside.