Mr Rob O'Neill

Cambridge University Hospitals NHS Foundation Trust

University departments
MRC Cancer Unit
NHS or other affiliations
Cambridge Oesophagogastric Centre

Position: Clinical Consultant
Personal home page:

PubMed journal articles - click here

Research Programme or Virtual Institute
Thoracic Cancer
Methods and technologies
Magnetic Resonance Imaging (MRI)
Tumour type interests
Recent publications:
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Key publications

RE Hughes, RJR Elliott, AF Munro, A Makda, JR O’Neill, T Hupp, NO Carragher. High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery. SLAS Discovery. 2020;25(7):770-782.  PMID: 32441181

S Rahman, RC Walker, MA LLoyd, BL Grace, GI van Boxel, FB Kingma, JP Ruurda, R van Hillegersberg, S Harris, S Parsons, S Mercer, EA Griffiths, JR O'Neill, R Turkington, R Fitzgerald, TJ Underwood, OCCAMS Consortium. Machine learning to predict early recurrence after oesophageal cancer surgery. British Journal of Surgery. 2020 Jul;107(8):1042-1052. PMID: 31997313

AM Frankell, S Jammula, X Li, G Contino, S Killcoyne, S Abbas, J Perner, L Bower, G Devonshire, E Ococks, N Grehan, J Mok, M O’Donovan, S MacRae, MD Eldridge, S Tavare, the OCCAMS consortium (RF Elliott, PAW Edwards, , H Chettouh, G Contini, E Gregson, S Zeki, L Smith, Z Abdullahi, R de la Rue, A Miremadi, S Malhotra, MI Smith, J Davies , C Crichton, N Carroll, P Safranek, A Hindmarsh, V Sujendran, R Turkington, SJ Hayes, Y Ang, SR Preston, S Oakes, I Bagwan, V Save , RJE Skipworth, TR Hupp, JR O'Neill, O Tucker, A Beggs, P Taniere, TJ Underwood, F Noble, J Owsley, H Barr, N Shepherd, O Old, J Lagergren, J Gossage, A Davies, F Chang, J Zylstra, G Sanders, R Berrisford, C Harden, D Bunting, M Lewis, E Cheong, B Kumar, SL Parsons, I Soomro, P Kaye, L Lovat, R Haidry, V Eneh, L Igali, M Scott, S Sothi, S Suortamo, S Lishman) and Fitzgerald RC. The landscape of selection in 551 Esophageal Adenocarcinomas defines genomic biomarkers for the clinic. Nature Genetics. 2019;51(3):506-516. PMID: 30718927

JR O’Neill. An Overview of Mass Spectrometry-based Methods for Functional Proteomics. Methods Mol Biol. 2019;1871:179-196. PMID: 30276741 

JR O’Neill, HS Pak, E Pairo-Castineira, V Save, S Paterson-Brown, R Nenutil, B Vojtesek, I Overton, A Scherl, TR Hupp. Quantitative Shotgun Proteomics unveils Candidate Novel Oesophageal Adenocarcinoma-Specific Proteins.  Molecular and Cellular Proteomics. 2017;16(6):1138-50. PMID: 28336725

 M Secrier, N de Silva, M Eldridge, J Bornschein, S MacRae, N Grehan, M O’Donovan, G Contino, T Yang, L Bower, H Chettouh, J Crawte, B Nutzinger, A Achilleos, P Edwards, A Lynch, S Tavaré, RC. Fitzgerald and the OCCAMS consortium (C-A J. Ong,  Z Abdullahi, I Debriram-Beecham, A Noorani, R Fels-Elliott, X Li, S Zeki, E Gregson, A Frankell, M Psung, M Barbera, L Smith, A Cluroe, A Miremadi, B Mahler-Araujo, S Malhotra, C Peters, R Hardwick, J Davies, H Ford, D Gilligan, P Safranek, A Hindmarsh, V Sudjendran, A Metz, N Carroll, R Turkington, SJ Hayes, Y Ang, S Preston, S Oakes, I Bagwan, V Save, RJE Skipworth, TR Hupp, JR O’Neill, O Tucker, D Alderson, P Taniere, TJ Underwood, F Noble, L Boulter, J Owsley, C Crichton, C Schusterreiter, H Barr, N Shepherd, P Townsend, J Lagergren, J Gossage, F Chang, J Zylstra,G Sanders, R Berrisford, C Harden, D Bunting, T Roques, J Nobes, M Lewis, SL Parsons, I Somooro, P Kaye, J Saunders, L Lovat, R Haidry, V Eneh, L Igali, I Welch, M Scott, S Sothi, S Suortamo, S Lishman, D Beardsmore).  Mutational signatures in esophageal adenocarcinoma reveal aetiologically distinct subgroups with therapeutic relevance.  Nature Genetics. 2016;48(10):1131-41 PMID: 27595477.

JR O'Neill, N Stephens, V Save, H Phillips, HM Kamel, PJ Driscoll, S Paterson-Brown. Defining a positive circumferential resection margin in oesophageal cancer and its implications for adjuvant treatment. British Journal of Surgery. 2013;100(8):1055-63. PMID: 23616367