Dr Simon Richardson
My research studies the stem cell biology and epigenetic dysregulation underlying B acute lymphoblastic leukaemia, the commonest cancer in children. Whilst it is treatable with chemotherapy in the majority of cases, patients who relapse or have certain genetic drivers have a very low survival rate and B-ALL remains one of the leading causes of death in childhood. Furthermore, survival rates from adult B-ALL remain poor. Using a combination of in vivo modelling, genome engineered cell lines, CRISPR screening and preclinical drug testing, my research is seeking to understand how mutations in epigenetic regulators generate this cancer and promote drug resistance, with the aim of using that knowledge to identify novel types of therapies for the most resistant cases.
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Leon T.E., Rapoz-D'Silva T., Bertoli C., Rahman S., Magnussen M., Philip B., Farah N., Richardson SE., Ahrabi S., Afonso Guerra-Assuncao J., Gupta R., Nacheva E.P., Henderson S., Herrero J., Linch D.C., de Bruin R.A.M. & Mansour M.R. EZH2 deficient T-cell acute lymphoblastic leukemia is sensitized to CHK1 inhibition through enhanced replication stress. Cancer Discovery. 2020; doi: 10.1158/2159-8290.CD-19-0789.
Richardson S.E., Brian D., Grandage V., Hough R., Kottaridis P., Mansour M., Payne E. & Khwaja A. Intensive chemotherapy is associated with poor overall survival in autoimmune disease-associated myeloid malignancies. HemaSphere. 2019;3(1):e164
Böiers C.*, Richardson S.E.*, Zriwil A., Turati V.A., Brown J., Wang D., Herrero J., Karlsson., Smith A.J.H., Jacobsen S.E.W. & Enver T. A human IPS model implicates embryonic B-myeloid fate restriction as a developmental susceptibility to B acute lymphoblastic leukemia-associated ETV6-RUNX1. Developmental Cell. 2018;44:362-377. *Equal contribution
Mathew NR, … Richardson S, … Zeiser R. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD mutant leukemia cells. Nature Medicine. 2018;24:282-291.
Böiers C, Gupta R, Nimmo R, Richardson SE, Wray JP & Enver T. Novel oncogenetic pathways in ALL. Hematology Education: the education program for the annual congress of the European Hematology Association 2015;9:1-6
Richardson SE, Wagner T & McNamara C. The Role of Functional Imaging in Lymphoma: Current Controversies and Future Directions. Lymphoma and Chronic Lymphocytic Leukaemias. 2014;4:21-29.
Richardson SE, Khan I, Rawstron A, Sudak J, Edwards N, Verfuerth S, Fielding AK, Goldstone A, Kottaridis P, Morris E, Benjamin R, Peggs KS, Thomson KJ, Vandenberghe E, Mackinnon S, Chakraverty R. Risk-stratified adoptive cellular therapy following allogeneic hematopoietic stem cell transplantation for advanced chronic lymphocytic leukaemia. British Journal of Haematology. 2013;160(5):640-8.
Richardson SE. Modelling how initiating and transforming oncogenes cooperate to produce a leukaemic cell state. Disease Models and Mechanisms. 2013;6(1):3-5.
Richardson SE, Sudak J, Warbey V, Ramsay A & McNamara C. Routine bone marrow biopsy is not necessary in the staging of Hodgkin lymphoma (CHL) patients in the FDG-PET era. Leukaemia & Lymphoma. 2012; 53(3):381-5.
Richardson SE & McNamara C. The management of classical Hodgkin’s lymphoma: past, present and future. Advances in Haematology. 2011; 2011. 865870.
Richardson S, Cwynarski K, Hughes D, Malhotra A, Prentice A & McNamara C. Patients undergoing high dose chemotherapy for primary CNS lymphoma should receive prophylactic thiamine to prevent Wernike’s encephalopathy. Br. J. Haematol. 2010; 149:899-901.
Richardson S, Pallot D, Hughes T & Littlewood T. Improving the management of neutropenic sepsis in the emergency department. Br. J. Haematol. 2009; 144(4):617-8.
C-H. Yang, K-C.G. Jeng, W-H. Yang, Y-L. Chen, C-C. Hung, J-W. Lin, S. Richardson, C.R.H. Martin, M.J. Waring & L. Sheh. Unusually Strong Positive Cooperativity in Binding of Peptides to Latent Membrane Protein-1 DNA Fragments of the Epstein-Barr Viral Gene. ChemBioChem 2006; 7(8):1187-96.