Dr Siddhartha Kar

University of Cambridge
Department of Public Health and Primary Care

Position: Homerton College Junior Research Fellow in Clinical Medicine
Personal home page: https://scholar.google.co.in/citations?user=WAXlOQ0AAAAJ&hl=en

PubMed journal articles - click here

Research description

My primary affiliation within the Cancer Research United Kingdom Cambridge Centre is with the ovarian cancer research programme.

I research inherited susceptibility to some of the most common cancer types in the world, with special emphasis on cancers of the ovary and the breast. I use a variety of approaches that leverage population-scale genomic data to identify common germline alleles, genes, cellular pathways, and causal clinical risk factors and molecular mechanisms underlying these cancer types.

I also maintain a keen interest in scientific and healthcare policy in India and have written on these topics in Nature and The Lancet.

I trained in medicine at the Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospital in Pune, India. I hold a master's degree in public health from the University of Texas at Houston in the United States and a PhD in epidemiology from the University of Cambridge in the United Kingdom, where I studied as a Gates Scholar.

Research Programme
Ovarian Cancer

Key publications

As first named author:

10. Kar SP, Berchuck A, Gayther SA, Goode EL, Moysich KB, Pearce CL, et al. Common genetic variation and susceptibility to ovarian cancer: Current insights and future directions. Cancer Epidemiol Biomarkers Prev. 2017 Jun.

9. Kar SP. Addressing underlying causes of violence against doctors in India. Lancet. 2017 20;389:1979–80.

8. Kar SP, Adler E, Tyrer J, Hazelett D, Anton-Culver H, Bandera EV, et al. Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci. Br J Cancer. 2017 Feb 14;116(4):524–35.

7. Kar SP, Beesley J, Amin Al Olama A, Michailidou K, Tyrer J, Kote-Jarai Zs, et al. Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types. Cancer Discov. 2016 Sep;6(9):1052–67.

6. Kar SP, Tyrer JP, Li Q, Lawrenson K, Aben KKH, Anton-Culver H, et al. Network-based integration of GWAS and gene expression identifies a HOX-centric network associated with serous ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2015 Oct;24(10):1574–84.

5. Kar SP, Seldin MF, Chen W, Lu E, Hirschfield GM, Invernizzi P, et al. Pathway-based analysis of primary biliary cirrhosis genome-wide association studies. Genes Immun. 2013 Apr;14(3):179–86.

4. Kar SP. Research funding: Indian science needs alternative investors. Nature. 2012 May 10;485(7397):174.

As author with an equal contribution to leading the manuscript as the first named author:

3. Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, et al. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Commun. 2016;7:12675.

2. Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, et al. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet. 2017 Mar.

1. Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, et al. Association analysis identifies 65 new breast cancer risk loci. Nature. 2017 Oct.