Professor Stephen Jackson

University of Cambridge
MISSION Therapeutics Ltd
Wellcome Trust Sanger Institute

University departments
Department of Biochemistry
University institutes
Wellcome Trust CRUK Gurdon Institute

Position: Professor
Personal home page: https://www.gurdon.cam.ac.uk/research/jackson

PubMed journal articles - click here

Professor Stephen Jackson is pleased to consider applications from prospective PhD students.

Research description

The main focus of research in our lab is to better understand how cells detect DNA damage and signal its presence to the DNA repair, transcription and cell cycle machineries. We believe that a deeper knowledge of these pathways will yield a better understanding of the diseases that can arise when such pathways are lost such as hereditary and sporadic cancer, neurodegeneration, developmental defects, immune deficiencies, infertility and premature ageing and will suggest new strategies for treating such diseases more effectively.

Research Programme
Cell and Molecular Biology
spj13
Recent publications:
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Key publications

Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair. Schmidt CK, Galanty Y, Sczaniecka-Clift M, Coates J, Jhujh S, Demir M, Cornwell M, Beli P, Jackson SP. Nature Cell Biology 2015;17, 1458-1470.

USP4 auto-deubiquitylation promotes homologous recombination. Wijnhoven P, Konietzny R, Blackford AN, Travers J, Kessler BM, Nishi R, Jackson SP. Molecular Cell 2015;60, 362-373.

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP. Science 2015; 347, 185-188.

Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP. Nature Cell Biology 2014;16, 1016-1026.

Chemical inhibition of NAT10 corrects defects of laminopathic cells. Larrieu D, Britton S, Demir M, Rodriguez R, Jackson SP. Science 2014;344, 527-532.

KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Kaidi A, Jackson SP. Nature 2013;498, 70-74.

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Galanty Y, Belotserkovskaya R, Coates J and Jackson SP. Genes & Development 2012;26, 1179-95.

Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S and Jackson SP. Nature Chemical Biology 2012;8, 301-10.

Human SIRT6 promotes DNA end resection through CtIP deacetylation. Kaidi A, Weinert BT, Choudhary C and Jackson SP. Science (New York, N.Y.) 2010;329, 1348-53.

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM and Jackson SP. Nature 2009;462, 935-9.

The DNA-damage response in human biology and disease. Jackson SP and Bartek J. Nature 2009;461, 1071-8.

CDK targets Sae2 to control DNA-end resection and homologous recombination. Huertas P, Cortés-Ledesma F, Sartori AA, Aguilera A and Jackson SP. Nature 2008;455, 689-92.

Human CtIP promotes DNA end resection. Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J and Jackson SP. Nature 2007;450, 509-14.

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Ahnesorg P, Smith P and Jackson SP. Cell 2006;124, 301-13.

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ and Jackson SP. Cell 2005;123, 1213-26.

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Falck J, Coates J and Jackson SP. Nature 2005;434, 605-11.

A DNA damage checkpoint response in telomere-initiated senescence. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP and Jackson SP. Nature 2003, 194-8.